Cannabinoid Receptor-Mediated Modulation of Gabaergic Transmission in the Basal Ganglia
Cannabinoids have been known to humanity for thousands of years and have benn used for religious, pharmaceutical and recreational purposes. However, it is only since 1964, when Goani and Mechoulam isolated the most psychoactive compound of cannabis sativa, Δ9-tetrahydrocannabinol, that the scientific interest for these compounds started to develop. In the early nineties, the cloning and pharmacological characterization of the brain cannabinoid receptor (CB1) by Matsuda et al. (1990) allowed researchers to begin to comprehensively investigate the physiological importance of cannabinoid receptor-mediated actions.
KeywordsBasal Ganglion Globus Pallidus Gaba Release GABAergic Transmission Gaba Uptake
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