Taurine 2 pp 257-262 | Cite as

Direct Inhibitory Effects of Taurine on Norepinephrine-Induced Contraction in Mesenteric Artery of Stroke-Prone Spontaneously Hypertensive Rats

  • Nanfang Li
  • Makoto Sawamura
  • Yasuo Nara
  • Katsumi Ikeda
  • Yukio Yamori
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)

Summary

The effect of taurine on vascular reactivity was investigated in the mesenteric artery of Wistar Kyoto (WKY), and stroke-prone spontaneously hypertensive rats (SHRSP). Administration of taurine significantly decreased blood pressure of SHRSP but not WKY. The mesenteric artery of taurine-treated SHRSP was excised to observe the contractile responses to transmural electrical stimulation and to several vasoactive substances. Vasocontraction induced by norepinephrine (NE) was significantly decreased by taurine. However, contraction elicited by the other substances tested was not affected. Consistently, when the vessels of SHRSP were pretreated with taurine in vitro, only the NE-induced vasocontraction was specifically attenuated. No effect was observed in WKY vessels. These results indicate that the hypotensive effect of taurine is accounted for at least in part its direct action on blood vessels.

Keywords

Mesenteric Artery Vascular Reactivity Vasoactive Substance Direct Inhibitory Effect Vascular Contraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Nanfang Li
    • 1
  • Makoto Sawamura
    • 1
  • Yasuo Nara
    • 1
  • Katsumi Ikeda
    • 1
  • Yukio Yamori
    • 1
  1. 1.Graduate School of Human and Environmental StudiesKyoto UniversityKyotoJapan

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