Taurine 2 pp 233-245 | Cite as

Effect of Treatment with β-Agonists on Tissue and Urinary Taurine Levels in Rats

Mechanism and Implications for Protection
  • Catherine J. Waterfield
  • Felix Carvalho
  • John A. Timbrell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)

Abstract

Administration of clenbuterol to rats in the drinking water over a four day period increased incorporation of [3H]leucine into muscle protein but did not result in an increase in body or muscle weight. However, both urinary and liver taurine were significantly reduced at the highest dose of clenbuterol (2 mg. kg−1 day−1). Salbutamol also reduced urinary levels of taurine in both rats and humans. The reduction in the body pool of taurine caused by β-agonists may be of concern as taurine has been shown to have protective properties.

Keywords

Muscle Protein Serum Total Protein Muscle Weight Adrenoceptor Agonist Leucine Incorporation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Catherine J. Waterfield
    • 1
  • Felix Carvalho
    • 2
  • John A. Timbrell
    • 1
  1. 1.The Department of ToxicologySchool of PharmacyLondonUK
  2. 2.Toxicology Laboratory, Faculdade de FarmaciaUnivesidade do PortoPortoPortugal

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