Phosphatidylinositol-3-Kinase Pathway is Stimulated by Fungal Lipid Containing Cocoa Butter Equivalents (CBE) in FMet-Leu-Phe (FMLP)- and Phorbolester (PMA)-Challenged Human Neutrophils

  • M. P. Roux
  • J. L. F. Kock
  • S. Nigam
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)

Abstract

It is well established that fungi produce fats and oils, although a commercial utilization of these processes with rare exception could not yet be achieved. The reason hereto lied primarily on the high costs of production. Recently, a novel biotechnological process for the production of fungal lipids from Mucor circinelloides by using acetic acid (a cheap carbon source) at sub-toxical levels as the starting substrate has been described (1). The products obtained were oil- and butter-like compounds depending upon the dissolved oxygen tension maintained (Figure 1). The analyses of the lipid demonstrated a γ-linolenic acid (GLA)-rich lipid (so-called fungal oil) and a stearic acid-rich lipid (so-called fungal butter) (2). This first report of low cost production of high value lipids thus raised a caveat for more consideration.

Keywords

Cocoa Butter Human Neutrophil Dissolve Oxygen Tension Cocoa Butter Equivalent Mucor Circinelloides 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • M. P. Roux
    • 1
  • J. L. F. Kock
    • 2
  • S. Nigam
    • 1
  1. 1.Eicosanoid Research Division Department of GynecologyUniversity Medical Hospital Benjamin FranklinBerlinGermany
  2. 2.Department of Microbiology and BiochemistryUniversity of the Orange Free StateBloemfonteinSouth Africa

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