Endothelin-1 as One of the Mediators of the Interaction between Endothelium and Platelets in Humans

  • Ralf Knöfler
  • Yumiko Takada
  • Akikazu Takada
  • Gerhard Weissbach
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)

Abstract

Endothelin-1 (ET-1) is an endothelium-derived peptide with multiple functions affecting the cardiovascular, renal, neuroendocrine, pulmonary and gastrointestinal system1,2. Elevated plasma levels of ET-1 were found in diseases associated with the activation of platelets, e.g. myocardial infarction, disseminated intravascular coagulation and diabetes. These findings prompted us to investigate the ET-1 effect on platelet aggregation in human whole blood and in platelet rich plasma (PRP).

Keywords

Platelet Aggregation Platelet Rich Plasma Disseminate Intravascular Coagulation Maximal Aggregation Platelet Poor Plasma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Ralf Knöfler
    • 1
  • Yumiko Takada
    • 2
  • Akikazu Takada
    • 2
  • Gerhard Weissbach
    • 1
  1. 1.Department of PediatricsMedical Faculty of the Technical University DresdenGermany
  2. 2.Department of PhysiologyHamamatsu University School of MedicineJapan

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