Evaluation of the Thyroid Function in Newborns by Means of Factor Analysis

  • P. Zagrodzki
  • R. Ratajczak
  • M. Rybakowa
  • R. Podsiadły

Abstract

In neonates the thyroid gland is very sensitive to iodine deficit. This hypersensitivity is due to a less efficient mechanism of adaptation to iodine deficiency (1). The main purpose of the present study was to evaluate the thyroid function in newborns for whom four different thyroid Iodine Deficiency Disorders (IDD) were diagnosed: hypothyroxinemia, transient hypothyroidism, hyperthyrotropinemia without goitre, and hyperthyrotropinemia with goitre. The study was carried out shortly after the iodine prophylaxis (salt iodisation) in Poland had been resumed after nearly 10 years of break. So, it was interesting to compare the evolution of particular disorders in subsequent years and the evolution of correlations between parameters used to diagnose cases. Some relevant insights were done by help of factor analysis, which aimed to explain the observed relations among parameters and to find basic casual influences on them. As a research instrument, factor analysis and other pattern recognition methods have been used in numerous studies dedicated to clinical practice and epidemiology (2–4).

Keywords

Factor Loading Thyroid Function Iodine Deficiency Pattern Recognition Method Iodine Deficiency Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    F. Delange, P. Bourdoux, M. Laurence, L. Paneva, P. Walfish, H. Willgerodt, in Iodine Deficiency in Europe: A Continuing Concern, F. Delange, J.T. Dunn, D. Glinoer, ed., Plenum Press, New York., pp. 199–207 (1993).CrossRefGoogle Scholar
  2. 2.
    D.L. Duewer, B.R. Kowalski, K.J. Clayson, R.J. Roby, Computers and Biomed.Res 11, 567–580 (1978).CrossRefGoogle Scholar
  3. 3.
    D. Coomans, M. Jonckheer, D.L. Massart, I. Broeckaert, P. Blockx, Anal.Chim.Acta 103, 409–415 (1978).CrossRefGoogle Scholar
  4. 4.
    R.T.P. Jansen, F.W550. Pijpers, G.A.J.M. de Valk, Anal.Chim.Acta 133, 1–18, (1981).CrossRefGoogle Scholar
  5. 5.
    D.F. Nordenberg, R. Ratajczak, M. Rybakowa, D. Tylek, G.F. Maberly, in: The damaged brain of iodine deficiency, J.B. Stanbury, ed., Cognizant Communication Corporation, New York, pp. 79–283 (1994).Google Scholar
  6. 6.
    Z. Szybinski et al., Endokynol. Pol. 44, 235–248 (1993).Google Scholar
  7. 7.
    M. Rybakowa et al., Endokrynol. Pol. 44, 249–258 (1993).Google Scholar
  8. 8.
    Document WHO/Nut/94.6, Indicators for assessing Iodine Deficiency Disorders and their control through salt iodisation, WHO, UNICEF, ICCIDD, Geneva, p. 16 (1994).Google Scholar
  9. 9.
    D. Glinoer, F. Delange, I. Laboureur, P. De Nayer, B. Lejeune, J. Kinthaert, P. Bourdoux, J.Clin. Endocrinol. Metab. 75,800–805,(1992).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • P. Zagrodzki
    • 1
    • 2
  • R. Ratajczak
    • 3
  • M. Rybakowa
    • 3
  • R. Podsiadły
    • 4
  1. 1.Department of Food Chemistry and Nutrition, Collegium MedicumJagiellonian UniversityKrakówPoland
  2. 2.Institute of Nuclear PhysicsKrakówPoland
  3. 3.Department of Pediatric Endocrinology, Polish-American Children’s Hospital, Collegium MedicumJagiellonian UniversityKrakówPoland
  4. 4.Chemical Physics Laboratory, Institute of ChemistryJagiellonian UniversityKrakówPoland

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