Usefulness of Plasma Zinc Protoporphyrin (ZPP) Dosage in the Assessment of Iron Status in the Iron Deficient Rat

  • M. Boudey
  • N. Aït-Oukhatar
  • M. H. Read
  • M. Mallet
  • F. Bureau
  • P. Arhan
  • D. Bouglé

Abstract

Iron is a mineral frequently deficient in diets of industrialised countries (1). Assessment of iron status still requires the determination of several parameters of iron metabolism (2). Heme is formed in the developing erythrocytes by insertion of iron into a formed porphyrin ring. In the event of insufficient iron supply or impaired iron utilisation, zinc is substituted for iron into porphyrin IX. The Zinc Protoporphyrin (ZPP) formed in the chelation process is stable and remains in the red cell for its 120 days of life span. Because ZPP concentration increases in iron deficiency, its dosage has been proposed as an early index of iron deficiency using haematofluorometry (3).

Keywords

Iron Deficiency Iron Intake Iron Status Iron Metabolism Liver Iron Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • M. Boudey
    • 1
  • N. Aït-Oukhatar
    • 1
  • M. H. Read
    • 2
  • M. Mallet
    • 3
  • F. Bureau
    • 4
  • P. Arhan
    • 1
  • D. Bouglé
    • 1
  1. 1.LPDN Laboratoire de Physiologie Digestive et NutritionnelleCHU de CaenCaenFrance
  2. 2.Laboratoire de PédiatrieCHU de CaenCaenFrance
  3. 3.Laboratoire d’Hématologie et de CytologieCHU de CaenCaenFrance
  4. 4.Laboratoire de Biochimie ACHU de CaenCaenFrance

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