Zinc and Growth Factors

  • D. Bouglé
  • F. Bureau

Abstract

Zinc is essential for growth in humans and animals. The features of Zn deficiency described by Prasad (1) include retarded growth, delayed sexual maturation, skin abnormalities and bone alterations such as open epiphyses. Delays in linear and bone growth and in bone maturation are common and early findings in various conditions associated with Zn deficiency. Zn deprivation causes in a few days decreases in taste acuity and appetite that leads to lower food intake. This anorexia has been related to an inability of the organism to metabolize nitrogen (2, 3). In previously deficient Zn supplemented subjects the increase in growth rate is associated with an increase in food intake and efficiency. Other non specific factors involved in the relationship between Zn and growth include increased activities of enzymes involved in nucleic acid metabolism, protein synthesis and cell division. Zn deficiency causes decrease in protein synthesis within a few days (4, 5); protein utilization is impaired in Zn deficiency (6). Food efficiency is decreased in Zn deficiency (8). Short-life protein levels are increased by Zn supplementation (7) which also leads to an enhancement of immunity and protection against infections. Besides these general effects of Zn on anabolism, protein synthesis, and therefore on growth, it has been observed that Zn deficiency impairs growth even in pair-fed animals on a control diet (4, 8, 9), implying that Zn has specific effects on growth. These effects are mediated by growth hormone and related factors.

Keywords

Growth Hormone Growth Hormone Level Growth Hormone Response Taste Acuity Partial Growth Hormone Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    A.S. Prasad, A. Miale, Z. Farid, H.H. Sanstead, A.R. Schillert, W.J. Darby, Arch. Int. Med. 111, 407–28 (1963).CrossRefGoogle Scholar
  2. 2.
    B.E. Golden, M.H.N. Golden, Am. J. Clin. Nutr. 34, 892–9 (1981).a.Google Scholar
  3. 3.
    M.H.N. Golden, B.E. Golden, Am. J. Clin. Nutr. 34, 900–8 (1981). b.Google Scholar
  4. 4.
    I. Dorup, T. Clausen, Br. J. Nutr. 66, 493–504 (1991).a.CrossRefGoogle Scholar
  5. 5.
    I. Dorup, A. Flyvbjerg, M.E. Everts, T. Clausen, Br. J. Nutr. 66, 505–21 (1991)b.CrossRefGoogle Scholar
  6. 6.
    J.M. Hsu, W.L. Anthony,/ Nutr. 105, 26–31 (1975).Google Scholar
  7. 7.
    J. Bates, C.J. McClain, Am. J. Clin. Nutr. 34, 1655–60 (1981).Google Scholar
  8. 8.
    M.S. Bolze, R.D. Reeves, F.E. Lindbeck, M.J. Eiders, Am. J. Physiol. 252, E21–6 (1987).Google Scholar
  9. 9.
    D. Dicks, A. Rojhani, Z.T. Cossack, Nutr. Res. 13, 701–13 (1993).CrossRefGoogle Scholar
  10. 10.
    M. Berelowitz, M. Szabo, L.A. Frohman, S. Firestone, L. Chu, R.L. Hintz, Science 212, 1279–81 (1981).CrossRefGoogle Scholar
  11. 11.
    S.Z. Ghavami-Maibodi, RJ. Collipp, M. Castro-Magana, C. Stewart, S.Y. Chen, Ann. Nutr. Metab. 27, 214–9 (1983).CrossRefGoogle Scholar
  12. 12.
    Y. Nishi, S. Hatano, K. Aihara, A. Fujie, M. Kihara, J. Am. Coll Nutr. 8, 93–7 (1989).Google Scholar
  13. 13.
    M. Kirchgeαner, H.P. Roth, Biol Tr. Eiern. Res. 7, 263–8 (1985).CrossRefGoogle Scholar
  14. 14.
    O. Thorlacius-Ussing, Neuroendocrinol. 45, 233–42 (1987).CrossRefGoogle Scholar
  15. 16.
    M.Y. Lorenson, D.L. Robson, L.S. Jacobs, J. Biol Chem. 258, 8618–22 (1983).Google Scholar
  16. 17.
    S. Focht, G, Fosmire, W.C. Hymer, FASEB J. 5, A940(Abs) (1991).Google Scholar
  17. 18.
    H.P. Roth, M. Kirchgeαner, Horm. Metab. Res. 26, 404–8 (1994).CrossRefGoogle Scholar
  18. 19.
    A.W. Root, G. Duckett, M. Sweetland, E.O. Reiter, J. Nutr. 109, 958–64 (1979).Google Scholar
  19. 20.
    YD. Coble Jr, C.W. Bardin, G.T. Ross, W.T. Darby, J. Clin. Endocrinol. Metab. 32, 361 (1976).CrossRefGoogle Scholar
  20. 21.
    RJ. Collipp, M. Castro-Magana, M. Petrovic, J. Thomas, T. Cheruvansky, S.Y. Chen, H. Sussman, Ann. Nutr. Metab. 26, 287–90 (1982).CrossRefGoogle Scholar
  21. 22.
    J. Brandào-Neto, V. Stefan, B.B. Mendoça, W. Bloise, V.B. Castro, Nutr. Res. 15, 335–58 (1995).CrossRefGoogle Scholar
  22. 23.
    T. Cheruvanky, M. Castro-Magana, S.Y Chen, PJ. Collipp, S.Z. Ghavami-Maibodi, Am. J. Clin. Nutr. 35, 668–70(1982).Google Scholar
  23. 24.
    K. Aihara, Y. Nishi, S. Hatano, M. Kihara, M. Ohta, K. Sakoda, T. Uozumi, T. Usui, J. Pediatr. Gastroenterol. Nutr. 4, 610–5(1985).CrossRefGoogle Scholar
  24. 25.
    G.E. Richards, N.M. Marshall, J. Am. Coll. Nutr. 2, 133–40 (1983).Google Scholar
  25. 26.
    A.S. Prasad, D. Oberleas, P. Wolf, J.P. Horwitz, J. Lab. Clin. Med. 73, 486–94 (1969).Google Scholar
  26. 27.
    N.M. Wright, J. Renault, B. Hollis, N.H. Bell, L.L. Key, J. Bone Mineral Res. 10, 127–31 (1995).CrossRefGoogle Scholar
  27. 28.
    G. Oner, B. Bhaumick, E.M. Bala, Endocrinology 114, 1860–3 (1984).CrossRefGoogle Scholar
  28. 29.
    T. Nakamura, S. Nishiyama, Y. Futagoishi-Suginohara, J. Matsuda, A. Higashi, J. Pediatr. 123, 65–9 (1993).CrossRefGoogle Scholar
  29. 30.
    R.E. Humbel, Eur. J. Biochem. 190, 445–62 (1990).CrossRefGoogle Scholar
  30. 31.
    Z.T. Cossack, Br. J. Nutr. 156, 163–9 (1986).CrossRefGoogle Scholar
  31. 32.
    Z.T. Cossack, J. Pediatr. Gastroenterol Nutr. 7, 441–5 (1988).CrossRefGoogle Scholar
  32. 33.
    S. Takahashi, M. Kajikawa, T. Umezawa, S.I. Takahashi, H. Kato, Y. Miura, T.J. Nam, T. Noguchi, H. Naito, Br. J. Nutr. 63, 521–34 (1990).CrossRefGoogle Scholar
  33. 34.
    W.L. Isley, L.E. Underwood, D.R. Clemmons, J. Clin. Invest. 71, 175–82 (1983).CrossRefGoogle Scholar
  34. 35.
    E.A. Droke, J.W. Spears, J.D. Armstrong, E.B. Kegley, R.B. Simpson, J. Nutr. 123, 13–9 (1993).Google Scholar
  35. 36.
    K.F. Michaelsen, G. Samuelson, T.W. Graham, B. Lönnerdal, Acta Paediatr. 83, 1115–21 (1994).CrossRefGoogle Scholar
  36. 37.
    R. Mokni, A. Chakar, F. Bleiberg-Daniel, J.L. Mahu, P.A. Walravens, P. Chappuis, J. Navarro, D. Lemonnier, Acta Paediatr. 82, 539–43 (1993).CrossRefGoogle Scholar
  37. 38.
    H.A. Ronaghi, J.G. Reinhold, M. Mahloudji, P. Ghavami, M.R. Spivey-Fox, J.A. Halsted, Am. J. Clin. Nutr. 27, 112–21 (1974).Google Scholar
  38. 39.
    J.C. Leek, C.L. Keen, J.B. Vogler, M.S. Golub, L.S. Hurley, A.G. Hendrickxs, M.E. Gershwin, Am. J. Clin. Nutr. 47, 889–95 (1988).Google Scholar
  39. 40.
    S. Haumont, J. Histochem. Cytochem. 19, 141–5 (1961).CrossRefGoogle Scholar
  40. 41.
    M. Yamaguchi, S. Kishi, M. Hashizume, Peptides 15, 1367–71 (1994).a.CrossRefGoogle Scholar
  41. 42.
    A. Suwarnasarn, J.C. Wallwork, L.I Lykken, F.N. Low, H.H. Sandstead, J. Nutr. 112, 1320–8 (1982).Google Scholar
  42. 43.
    M. Yamaguchi, R. Yamaguchi, Biochem. Pharmacol 35, 773–7 (1986).CrossRefGoogle Scholar
  43. 44.
    B.S. Moonga, D.W. Dempster, J. Bone Mineral Res. 10, 453–7(1995).CrossRefGoogle Scholar
  44. 45.
    O. Lema, H.H. Sandstead, Fed. Proc. 29, 297 (1970).Google Scholar
  45. 46.
    W.H. Daughaday, L.S. Phillips, A.C. Herington, Ann. Rev. Physiol 37, 211–44 (1975).CrossRefGoogle Scholar
  46. 47.
    C.W. Denko, M. Petricevic, M.W. Whitehouse, Int. J. Tissue Reac. 3, 121–5(1981).Google Scholar
  47. 48.
    F. Fernandez-Madrid, A.S. Prasad, D. Oberleas, J. Lab. Clin. Med. 82, 951–61 (1973).Google Scholar
  48. 49.
    A.S. Prasad, F. Fernandez-Madrid, J.F. Ryan, Am. J. Physiol. 236, E272–5 (1979).Google Scholar
  49. 50.
    M. Yamaguchi, M. Hashizume, Moll. Cell. Biochem. 136, 163–9 (1994).bCrossRefGoogle Scholar
  50. 51.
    T. Matsui, M. Yamaguchi, Peptides 16, 1063–68 (1995).CrossRefGoogle Scholar
  51. 52.
    J.M. Hock, M. Centrella, E. Canalis, Endocrinology 122, 254–60 (1988).CrossRefGoogle Scholar
  52. 53.
    L.S. Phillips, A.T. Orawski, D.C. Belosky, Endocrinology 103, 121–7 (1978).CrossRefGoogle Scholar
  53. 54.
    S. Kemp, R.T. Hintz, Endocrinology 106, 744–9 (1980).CrossRefGoogle Scholar
  54. 55.
    H.H. Sansdtead, A.S. Prasad, A.R. Schulert, Z. Farid, A. Miale Jr, S. Bassily, W.J. Darby, Am. J. Clin. Nutr. 20, 422–42 (1967).Google Scholar
  55. 56.
    M. Castro-Magana, P.J. Collipp, S.Y Chen, T. Cheruvanky, V.T. Maddaiah, Am. J Dis. Child. 135, 322–5 (1981).Google Scholar
  56. 57.
    L. Wada, J.C. King, J. Nutr. 116, 1045–53 (1986).Google Scholar
  57. 58.
    W.P. Pimenta, J. Brandào-Neto, P.R. Curi, Tr. Eiern. Med. 9, 34–7 (1992).Google Scholar
  58. 59.
    T. Nakamura, A. Higashi, S. Nishiyama, S. Fujimoto, I. Matsuda, Diabetes Care 14, 553–7 (1991).CrossRefGoogle Scholar
  59. 60.
    J. Brandàgo-Neto, J.G.H. Vieira, T. Shuhama, E.M.K. Russo, R.V. Piesco, P.R. Curi, Biol. Tr. Eiern. Res. 24, 73–82 (1990).CrossRefGoogle Scholar
  60. 61.
    J. Quarterman, C.F. Mills. W.R. Humphries, Biochem. Biophys Res. Comm. 25, 354–8 (1966).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • D. Bouglé
    • 1
  • F. Bureau
    • 2
  1. 1.Laboratoire de Physiologie Digestive et NutritionnelleService de Pédiatrie AFrance
  2. 2.Laboratoire de Biochimie ACentre Hospitalo Universitaire de CaenFrance

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