Copper-Histidine and -NSAID Complexes in Fenton Chemistry
At first sight, the behaviour of copper with respect to inflammation may seem paradoxical. On the one hand, copper exerts antiinflammatory activity. It has long been known that copper complexes of non-steroidal antiinflammatory drugs (NSAIDs) are more effective than parent molecules and that substances inactive by themselves may become antiinflammatory when administered with copper. It has been suggested from this that the active metabolites of NSAIDs are the complexes they form with endogenous copper (1). On the other hand, it is no longer debated that copper, like iron, can act as a catalyst in Fenton-type reactions to produce hydroxyl radicals (2) which are key mediators of the inflammatory process (3).
KeywordsScavenge Activity Copper Complex Anthranilic Acid Produce Hydroxyl Radical Speciation Calculation
Unable to display preview. Download preview PDF.