Engineering Stealth™ Liposome Surfaces: Exercises in Colloid Chemistry Principles
Liposome bilayers have been attractive tools mainly as models of biological membranes and as delivery devices. Almost immediately after being widely accepted as membrane mimicking models, numerous studies appeared which used liposomes as carrier vehicles of other molecules (Gregoriadis, 1988). Due to their ability to act as “solvents” for both lipophilic (lipid bilayer phase) and hydrophilic (inner aqueous phase) molecules, liposomes have been used to deliver enzymes, genetic material, anticancer drugs (eg. doxorubicin), agents for diagnostic imaging and antibacterials, to name only a few. Liposomes have also proved particularly useful as general vaccine adjuvants (for example, there is already a liposome-based vaccine against hepatitis A), surfactant providers for newborn babies suffering from lung surfactant deficiency, and in the formulation of cosmetics as evidenced by the plethora of commercial cosmetic products claiming to contain liposomes.
KeywordsBlock Copolymer Phospholipid Vesicle Steric Stabilization Soybean Lecithin Liposome Dispersion
Unable to display preview. Download preview PDF.
- Gregoriadis, G., e.d., 1988, “Liposomes as Drug Carriers — Recent Trends and Progress”, John Wiley & Sons Ltd., London.Google Scholar
- Israelachvili, J. N., “Intermolecular and Surface Forces”, 1985, Academic Press, New York.Google Scholar
- Kostarelos, K., Luckham, P.F., and Tadros, Th.F., 1998a, Interaction of block copolymers of the polyethylene oxide — polypropylene oxide type with soybean lecithin vesicles, Langmuir, in press.Google Scholar
- Kostarelos, K., Luckham, P.F., and Tadros, Th.F., 1998b, Investigating the steric stabilization of phospholipid vesicles by block copolymers: studies of vesicle flocculation and osmotic swelling caused by monovalent and divalent cations, J.Chem. Soc. Faraday Trans. in press.Google Scholar
- de Kruijff, B., de Gier, J., van Hoogevest, P., van der Steen, N., Taraschi, T.F., and de Kroon, T., 1991, Effects of an integral membrane glycoprotein on phospholipid vesicle fusion, in “Membrane Fusion”, J. Wilschut and D. Hoekstra, eds., Marcel Dekker, New York.Google Scholar
- Lasic, D.D, “Liposomes: from Physics to Applications”, 1993, Elsevier, Amsterdam.Google Scholar
- Tadros, Th.F., ed., 1982, “The Effect of Polymers on Dispersion Properties”, Academic Press, London.Google Scholar