Engineering Stealth™ Liposome Surfaces: Exercises in Colloid Chemistry Principles

  • Kostas Kostarelos
Chapter
Part of the NATO ASI Series book series (NSSA, volume 300)

Abstract

Liposome bilayers have been attractive tools mainly as models of biological membranes and as delivery devices. Almost immediately after being widely accepted as membrane mimicking models, numerous studies appeared which used liposomes as carrier vehicles of other molecules (Gregoriadis, 1988). Due to their ability to act as “solvents” for both lipophilic (lipid bilayer phase) and hydrophilic (inner aqueous phase) molecules, liposomes have been used to deliver enzymes, genetic material, anticancer drugs (eg. doxorubicin), agents for diagnostic imaging and antibacterials, to name only a few. Liposomes have also proved particularly useful as general vaccine adjuvants (for example, there is already a liposome-based vaccine against hepatitis A), surfactant providers for newborn babies suffering from lung surfactant deficiency, and in the formulation of cosmetics as evidenced by the plethora of commercial cosmetic products claiming to contain liposomes.

Keywords

Block Copolymer Phospholipid Vesicle Steric Stabilization Soybean Lecithin Liposome Dispersion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Kostas Kostarelos
    • 1
  1. 1.Department of Chemical Engineering & Chemical Technology, Imperial College of Science, Technology and MedicineUniversity of LondonLondonUK

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