Interactions between Blood Components and Artificial Surfaces

  • Karin D. Caldwell
Chapter
Part of the NATO ASI Series book series (NSSA, volume 300)

Abstract

Strategies for designing “stealth” therapeutic systems largely coincide with those governing the search for materials suitable to serve as artificial organs and prosthetic devices in contact with blood and other living tissues. In both cases, one strives to design surfaces that will avoid the triggering of inflammatory responses to the foreign material. Many times, there is also a need to link a homing device or bioactive ligand to the surface, in which case the mode of linking must leave the often marginally stable ligand in an active state. Beyond these common concerns, the biomaterials community also focuses on the specific tasks of avoiding a trigger of the clotting cascade and suppressing the potential for bacterial colonization, both issues related to the large size of the typical implant compared to that of a liposome or other circulating drug release vehicle. The following presentation will summarize ongoing efforts to devise some general techniques for preparing surfaces suitable to serve as biomaterials.

Keywords

American Chemical Society Protein Adsorption Triblock Copolymer Adsorbed Fibrinogen Pyridyl Disulfide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Karin D. Caldwell
    • 1
  1. 1.Center for Biopolymers at Interfaces, Department of BioengineeringUniversity of UtahSalt Lake CityUSA

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