Taurine 3 pp 129-135 | Cite as

Taurine Improves Angiotensin II-Induced Hypertrophy of Cultured Neonatal Rat Heart Cells

  • Kyoko Takahahsi
  • Mitsuhiro Azuma
  • Akemichi Baba
  • Stephen Schaffer
  • Junichi Azuma
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)

Abstract

The effect of taurine on angiotensin II-induced hypertrophy of cultured neonatal rat heart cells (myocytes and nonmyocytes) was examined. Angiotensin II (1–100 nM) alone caused an increase in the rate of protein synthesis and the surface area of myocytes without altering the rate of DNA synthesis or cell number. It also mediated an increase in DNA synthesis and in cell number of nonmyocytes. Exposure of the cells to taurine (20 mM) in the absence of angiotensin II had no effect on either hyperplastic growth or hypertrophy of the two types of cultured cardiac cells. However, myocytes pretreated with 20 mM taurine exhibited reduced responsiveness to angiotensin II. Following a 24 hr pretreatment with 20 mM taurine, the stimulation in protein synthesis by angiotensin II (1 nM) was significantly suppressed. Similarly, taurine treatment of nonmyocytes reduced the degree of angiotensin II-induced promotion of hyperplastic growth (DNA synthesis and cell number). Finally, taurine partially prevented the rise in [Ca2+]i mediated by angiotensin II in cardiac cells.

The present results indicate that taurine is an effective inhibitor of angiotensin II action. The possibility that the beneficial effects of taurine in the treatment of heart failure might be related to its suppression of angiotensin II-mediated cellular responses is discussed.

Keywords

Cardiac Myocytes Cardiac Cell Cardiac Fibroblast Cell Sheet Thymidine Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Kyoko Takahahsi
    • 1
  • Mitsuhiro Azuma
    • 1
  • Akemichi Baba
    • 2
  • Stephen Schaffer
    • 3
  • Junichi Azuma
    • 1
  1. 1.Department of Clinical Evaluation of Medicines and TherapeuticsOsaka UniversityOsakaJapan
  2. 2.Department of Pharmacology, Faculty of Pharmaceutical ScienceOsaka UniversityOsakaJapan
  3. 3.Department of PharmacologyUniversity of South Alabama, School of MedicineMobileUSA

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