Taurine 3 pp 115-119 | Cite as

Effect of Taurine on Excitation-Contraction Coupling of Extensor Digitorum Longus Muscle of Dystrophic MDX Mouse

  • Annamaria De Luca
  • Sabata Pierno
  • Claudia Camerino
  • Ryan J. Huxtable
  • Diana Conte Camerino
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)

Abstract

Dystrophin is a cytoskeletal protein associated with the sarcolemma. Genetic depletion of the protein leads to Duchenne muscular dystrophy (DMD) and dystrophic conditions in animals such as the mdx mouse9. Mechanical weakness of the sarcolemma during the stress of contraction can account for an abnormal calcium entry in the cell that in turn triggers proteolysis-dependent dystrophic muscle necrosis5,7,9. This mechanism can also account, in a positive feedback loop, for the increased activity of calcium-selective leak ion channels recorded in dystrophinless muscle fibers15. The increased cytosolic calcium is also responsible for longer calcium transients in the dystrophinless fibers7,14, which may affect muscle contractile properties. In skeletal muscle, contraction is triggered mainly by the calcium ions released from the sarcoplasmic reticulum due to depolarization of the sarcolemma and transverse tubules11. Nevertheless, higher cytosolic calcium levels can affect the rate of calcium release and reuptake1,14, thus modifying the excitation-contraction coupling mechanism.

Keywords

Sarcoplasmic Reticulum Duchenne Muscular Dystrophy Extensor Digitorum Longus Duchenne Muscular Dystrophy Mechanical Threshold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Annamaria De Luca
    • 1
  • Sabata Pierno
    • 1
  • Claudia Camerino
    • 2
  • Ryan J. Huxtable
    • 2
  • Diana Conte Camerino
    • 1
  1. 1.Unit of Pharmacology, Department of Pharmacobiology, Faculty of PharmacyUniversity of BariBariItaly
  2. 2.Department of PharmacologyCollege of Medicine, University of ArizonaTucsonUSA

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