The Role of Integrin αvβ3 in Cell Survival and Angiogenesis
The outgrowth of vasculature from pre-existing blood vessels is known as angiogenesis. The formation of new blood vessels facilitates physiological processes of embryonic development, the female reproductive cycle and wound-healing (Folkman (1995)). However, deregulated angiogenesis plays a critical role in various pathological mechanisms such as solid tumor formation, metastasis, childhood hemangiomas, diabetic retinopathy, macular degeneration, psoriasis and in inflammation related diseases such as rheumatoid arthritis, osteoarthritis and ulcerative colitis (Folkman (1995)). In particular, the expansion of solid tumors beyond a minimal size is critically dependent on neovascularization to supply oxygen, nutrients and growth factors. Angiogenesis is also crucial for the formation of metastases at secondary sites and accordingly, the degree of vascularization of certain tumors is correlated with a poor clinical prognosis and an increased risk of metastasis (Wedner (1995)).
KeywordsEndothelial Cell Survival Poor Clinical Prognosis Female Reproductive Cycle Copyright Permission Angiogenic Blood Vessel
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