Vascular Regulation at Sub Millimeter Range
Sources of Intrinsic Signals for High Resolution Optical Imaging
Chapter
Abstract
The idea that electrical activity is coupled to microvascular changes is not new. Already a century ago, Roy and Sherrington (1890) postulated that “the brain possesses an intrinsic mechanism by which its vascular supply can be varied locally in correspondence with local variations of functional activity”. Later studies have indeed demonstrated that there is a strong coupling between neuronal activity, local metabolic activity, and blood flow (Kety et al., 1955; Lassen and Ingvar 1961; Sokoloff, 1977; Raichle et al., 1983; Fox et al., 1986). Modern neuroimaging techniques have used signals that originate from metabolic activity or vascular response because the monitoring and precise localization of such signals sources is often better than those which originate directly from electrical activity.
Keywords
Mapping Signal Imaging Spectroscopy Vascular Regulation Intrinsic Signal Intrinsic Optical Signal
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