In Vivo Survival of Human Energy-Replete Carrier Erythrocytes

  • Murray D. Bain
  • Bridget E. Bax
  • Peter J. Talbot
  • E. John Parker-Williams
  • Ronald A. Chalmers

Abstract

Erythrocytes have been proposed as carriers of encapsulated therapeutic agents. Encapsulation of therapeutic agents within erythrocytes with a normal mean cell life range of 89 to 131 days (normal half-life of 19 to 29 days) should limit the vascular clearance of the administered drug thus reducing the dosage and frequency of therapeutic interventions.

Keywords

Adenosine Deaminase Surface Counting Citrate Dextrose 51Cr Activity Carrier Erythrocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bax, B.E., Bain, M.D., Ward, C.P., Fensom, A.H. and Chalmers, R.A. The entrapment of mannose-terminated glucocerebrosidase (Alglucerase) in human carrier erythrocytes. Biochem. Soc. Trans. 24: 441S (1996a).PubMedGoogle Scholar
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Murray D. Bain
    • 1
  • Bridget E. Bax
    • 1
  • Peter J. Talbot
    • 2
  • E. John Parker-Williams
    • 2
  • Ronald A. Chalmers
    • 1
  1. 1.Paediatric Metabolism Unit, Department of Child HealthSt. George’s Hospital Medical SchoolLondonUK
  2. 2.Department of HaematologySt. George’s Hospital Medical SchoolLondonUK

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