Rat Carrier Erythrocytes Circulate and Arrive to Organs
Different delivery systems are currently used in therapy. They have the advantage of protecting the active substance from rapid clearance and avoiding toxic side effects. Among the many carrier systems proposed12, RBCs have many desirable properties: they are naturally biodegradable and may stay in circulation over prolonged periods of time11,25; RBCs are easily obtainable and large amounts of material can be entrapped in a small volume of cells by hypotonic dialysis; autologous cells elicit little or no immune response7,16,20.
KeywordsCarbonic Anhydrase Human Erythrocyte Encapsulation Process Sodium Chromate Organ Uptake
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