Hantaviruses

  • James W. LeDuc

Abstract

Hantaviruses belong to a recently recognized genus within the family Bunyaviridae. The prototype is Hantaan virus, causative agent of Korean hemorrhagic fever of Korea. This virus was first described in 1978(60); since then several related viruses have been recovered from humans, rodents, and other small mammals. Human disease caused by these viruses is characterized by acute fever, a tubular renal lesion, and in some instances a life-threatening capillary leak syndrome, often accompanied by hemorrhagic manifestations.

Keywords

Hemorrhagic Fever With Renal Syndrome Hantavirus Infection Nephropathia Epidemica Acute Viral Infection Hantaan Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Antic, D., Kang, C. Y., Spik, K., Schmaljohn, C., Vapalahti, O., and Vaheri, A., Comparison of the deduced gene products of the L, M and S genome segments of hantaviruses, Virus Res. 24: 35–46 (1992).PubMedCrossRefGoogle Scholar
  2. 2.
    Antoniades, A., Grekas, D., Rossi, C. A., and LeDuc, J. W., Isolation of a hantavirus from a severely ill patient with hemorrhagic fever with renal syndrome in Greece, J. Infect. Dis. 156: 1010–1013 (1987).PubMedCrossRefGoogle Scholar
  3. 3.
    Arikawa, J., Takashima, I., Hashimoto, N., Morita, C., Sugiyama, K., Matsuura, Y., Shiga, S., and KrrAmura, T., Epidemiological studies of hemorrhagic fever among urban rats in two islands in Tokyo Bay, Japan, Acta V irol. 29: 66–72 (1985).Google Scholar
  4. 4.
    Arthur, R. R., Lofts, R. S., Gomez, J., Glass, G. E., LeDuc, J. W., and Childs, J. E., Grouping of hantaviruses by small (S) genome segment polymerase chain reaction and amplification of viral Rna from wild-caught rats, Am. J. Trop Med. Hyg. 47: 210–224 (1992).PubMedGoogle Scholar
  5. 5.
    Avsic-Zupanc, T., Xiao, S.-Y., Stojanovic, R., Stojanovic, R., Gligic, A., Van Der Groen, G., and LeDuc, J. W., Characterization of Dobrava virus: A hantavirus from Slovenia, Yugoslavia, J. Med. Virol. 38: 132–137 (1992).CrossRefGoogle Scholar
  6. 6.
    Brummer-Korvenkontio, M., Manni, T., Ukkonen, S., and Vaheri, A., Detection of hemagglutination-inhibiting antibodies in patients with nephropathia epidemica and Korean Hemorrhagic fever by using Puumala virus cell culture antigen, J. Infect. Dis. 153: 997–998 (1986).CrossRefGoogle Scholar
  7. 7.
    Brummer-Korvenkontio, M., Vaheri, A., Von Bonsdorff, C. H., Vuorimies, J., Manni, T., Penttinen, K., Oker-Blom, N., and Laehdvirta, J., Nephropathia epidemica: Detection of antigen in bank voles and serologic diagnosis of human infection, J. Infect. Dis. 141: 131–134 (1980).CrossRefGoogle Scholar
  8. 8.
    Burek, K. A., Rossi, C. A., LeDuc, J. W., and Yuill, T. M., Serologic and virologic evidence of a Prospect Hill-like hanta-virus in Wisconsin and Minnesota, Am. J. Trop. Med. Hyg. 51: 286–294 (1994).PubMedGoogle Scholar
  9. 9.
    Centers For Disease Control, Update: Outbreak of hanta-virus infection, Morbid. Mortal. Week. Rep. 42: 441–443 (1993).Google Scholar
  10. 10.
    Centers For Disease Control, Update: Hantavirus pulmonary syndrome-United States, 1993, Morbid. Mortal. Week. Rep. 42: 816–820 (1993).Google Scholar
  11. 11.
    Carey, D. E., Reuben, R., Panicker, K. N., Shope, R. E., and Myers, R. M., Thottapalayam virus: A presumptive arbovirus isolated from a shrew in India, Indian J. Med. Res. 59: 1758–1760 (1971).PubMedGoogle Scholar
  12. 12.
    Casals, J., Henderson, B. E., Hoogstraal, H., Johnson, K. M., and Shelokov, A., A review of Soviet viral hemorrhagic fevers, 1969, J. Infect. Dis. 122: 437–453 (1970).PubMedCrossRefGoogle Scholar
  13. 13.
    Childs, J. E., Glass, G. E., Korch, G. W., Arthur, R. R., Shah, K. V., Glasser, D., Rossi, C., and LeDuc, J. W., Evidence of human infection with a rat-associated Hantavirus in Baltimore, Maryland, Am. J. Epidemiol. 127: 875–878 (1988).PubMedGoogle Scholar
  14. 14.
    Childs, J. E., Glass, G. E., Korch, G. W., and LeDuc, J. W., Prospective seroepidemiology of hantaviruses and population dynamics of small mammal communities of Baltimore, Maryland, Am. J. Trop. Med. Hyg. 37: 648–662 (1987).PubMedGoogle Scholar
  15. 15.
    Childs, J. E., Glass, G. E., Korch, G. W., and Leduc, J. W., The ecology and epizootiology of hantaviral infections in small mammal communities of Baltimore: A review and synthesis, Bull. Soc. Vector Ecol. 13: 113–122 (1988).Google Scholar
  16. 16.
    Childs, J. E., Korch, G. W., Glass, G. E., Leduc, J. W., and Shah, K. V., Epizootiology of Hantavirus infections in Baltimore: Isolation of a virus from Norway rats, and characteristics of infected rat populations, Am. J. Epidemiol. 125: 55–68 (1987).Google Scholar
  17. 17.
    Childs, J. E., Korch, G. W., Smith, G. A., Terry, A. D., and LeDuc, J. W., Geographical distribution and age-related prevalence of antibody to Hantaan-like virus rat population of Baltimore, Maryland, Usa, Am. J. Trop Med. Hyg. 34: 385–387 (1985).PubMedGoogle Scholar
  18. 18.
    Chu, Y. K., Rossi, C., LeDuc, J. W., Lee, H. W., Schmaljohn, C. S., and Dalrymple, J. M., Serological relationships among viruses in the Hantavirus genus, family Bunyaviridae, Virology 198: 196–204 (1994).PubMedCrossRefGoogle Scholar
  19. 19.
    Cohen, M. S., Kwei, H.-E., Chin, C.-C., and GE, H.-C., Cns manifestations of epidemic hemorrhagic fever, Arch. Intern. Med. 143: 2070–2072 (1983).PubMedCrossRefGoogle Scholar
  20. 20.
    Dalrymple, J. M.,Plaque assay and plaque-reduction neutralization tests, in: Manual of Hemorrhagic Fever with Renal Syndrome (H. W. Lee and J. M. Dalrymple, Eds.), pp. 102–106, World Health Organization, Seoul, Korea, 1989.Google Scholar
  21. 21.
    Dantas, J. R., JR., Okuno, Y., Asada, H., Tamura, M., Takahashi, M., Tanishite, O., Takahasi, Y., Kurata, T., and Yamanishi, K., Characterization of glycoproteins of viruses causing hemorrhagic fever with renal syndrome (Hfrs) using monoclonal antibodies, Virology 151: 379–384 (1986).PubMedCrossRefGoogle Scholar
  22. 22.
    Desmyter, J., LeDuc, J. W., Johnson, K. M., Deckers, C., Brasseur, F., and Van Ypersele DE Strihou, C., Laboratory rat associated outbreak of haemorrhagic fever with renal syndrome due to Hantaan-like virus in Belgium, Lancet 2: 1445–1448 (1983).Google Scholar
  23. 23.
    Diglistic, G., Xiao, S.-Y., Gligic, A., Obradovic, M., Stojanovic, R., Velimirovic, D., Lukac, V., Rossi, C. A., and LeDuc, J. W., Isolation of a Puumala-like virus from Mus musculus captured in Yugoslavia and its association with severe hemorrhagic fever with renal syndrome, J. Infect. Dis. 169: 204–207 (1994).CrossRefGoogle Scholar
  24. 24.
    Earle, D. P., Analysis of sequential physiologic derangements in epidemic hemorrhagic fever, Am. J. Med. 16: 690–709 (1954).PubMedCrossRefGoogle Scholar
  25. 24a.
    Elliott, L. H., Ksiazek, T. G., Rollin, P. E., SpiropoÜLou, C. F., Morzunov, S., Monroe, M., Goldsmith, C. S., Humphrey, C. D., Zaki, S. R., Krebs, J. W., Maupin, G., Gage, K., Childs, J. E., Nichol, S. T., and Peters, C. J., Isolation of the causative agent of Hantavirus pulmonary syndrome, Am. J. Trop. Med. Hyg. 51: 102–108 (1994).PubMedGoogle Scholar
  26. 25.
    Elwell, M. R., Ward, G. S., Tingpalapong, M., and LeDuc, J. W., Serologic evidence of Hantaan-like virus in rodents and man in Thailand, Southeast Asian J. Trop. Med. Public Health 16: 349–354 (1985).PubMedGoogle Scholar
  27. 26.
    French, G. R., Foulke, R. S., Brand, O. A., Eddy, G. A., Lee, H. W., and Lee, P.-W., Propagation of etiologic agent of Korean hemorrhagic fever in a cultured continuous cell line of human origin, Science 211: 1046–1048 (1981).PubMedCrossRefGoogle Scholar
  28. 27.
    Gajdusek, D. C., Virus hemorrhagic fevers, J. Pediatr. 60: 841–857 (1962).PubMedCrossRefGoogle Scholar
  29. 28.
    Gavrilovskaya, I. N., Apekina, N. S., Myasnikov, Y. A., Bernshtein, A. D., Ryltseva, E. V., Gorbachkova, E. A., and Chumakov, M. P., Features of circulation of hemorrhagic fever with renal syndrome (Hfrs) virus among small mammals in the European U.S.S.R., Arch. Virol. 75: 313–316 (1983).PubMedCrossRefGoogle Scholar
  30. 29.
    Glass, G. E., Childs, J. E., Korch, G. W., and LeDuc, J. W., Association of intraspecific wounding with hantaviral infection in wild rats (Rattus norvegicus), Epidemiol. Infect. 101: 459–472 (1988).PubMedCrossRefGoogle Scholar
  31. 30.
    Glass, G. E., Watson, A. J., Leduc, J. W., and Childs, J. E., Domestic cases of hemorrhagic fever with renal syndrome in the United States, Nephron 68: 48–51 (1994).PubMedCrossRefGoogle Scholar
  32. 31.
    Glass, G. E., Watson, A. J., LeDuc, J. W., Kelen, G. D., Quire, T. C., and Childs, J. E., Infection with a ratborne hantavirus in US residents is consistently associated with hypertensive renal disease, J. Infect. Dis. 167: 614–620 (1993).PubMedCrossRefGoogle Scholar
  33. 32.
    Gligic, A., Dimkovic, N., Xia°, S.-Y, Buckle, G. J., Jovanovtc, D., Velimirovic, D., Stojanovic, R., Obradovic, M., Diglistic, G., Micic, J., Asher, D. M., LeDuc, J. W., Yanagihara, R., and Gajdusek, D. C., Belgrade virus: A new hantavirus causing severe hemorrhagic fever with renal syndrome in Yugoslavia, J. Infect. Dis. 166: 113–120 (1992).PubMedCrossRefGoogle Scholar
  34. 33.
    Gligic, A., Frusic, M., Obradovic, M., Stojanovic, R., Hlaca, D., Gibbs, C. J., JR., Yanagihara, R., Calisher, C. H., and Gajdusek, D. C., Hemorrhagic fever with renal syndrome in Yugoslavia: Antigenic characterization of hantaviruses isolated from Apodemus flavicollis and Clethrionomys glareolus, Am. J. Trop. Med. Hyg. 41: 109–115 (1989).PubMedGoogle Scholar
  35. 33a.
    Gligic, A., Stojanovic, R., Obradovic, M., Hlaca, D., Dimkovic, N., Diglisic, G., Lukac, V., Ler, Z., Bogdanovic, R., Antonijevic, B., Ropac, D., Avsic-Zupanc, T., LeDuc, J. W., Ksiazek, T., Yanagihara, R., and Gajdusek, D. C., Hemorrhagic fever with renal syndrome in Yugoslavia: Epidemiologic and epizootiologic features of a nationwide outbreak in 1989, Eur. J. Epidemiol. 8: 816–825 (1992).PubMedCrossRefGoogle Scholar
  36. 34.
    Gonzales, J R, Mccormick, J. B., Banin, D., Grutun, J. P., Meunier, D. Y., Dournon, E., and Georges, A. J., Serological evidence for Hantaan-related virus in Africa, Lancet 2: 1036–1037 (1984).CrossRefGoogle Scholar
  37. 35.
    Grankvist, O., Jut°, R, Settergren, B., Ahlm, C., Bjermer, L., Linderholm, M., Tarnvik, A., and Wadel, G., Detection of nephropathia epidemica virus Rna in patient samples using a nested primer-based polymerase chain reaction, J. Infect. Dis. 165: 934–937 (1992).PubMedCrossRefGoogle Scholar
  38. 36.
    Gresikova, M., Rajcani, J., Sekeyova, M., Brummerkorvenkontio, M., Kozuch, O., Labuda, M., Turek, R., Weismann, R, Nosek, J., and Lysy, J., Haemorrhagic fever virus with renal syndrome in small rodents in Czechoslovakia, Acta Virol. 28: 416–421 (1984).PubMedGoogle Scholar
  39. 37.
    Gresikova, M., and Sekeyova, M., A simple method of preparing a complement-fixing antigen from the virus of haemorrhagic fever with renal syndrome (western type), Acta Virol. 22: 272–275 (1988).Google Scholar
  40. 38.
    Huggins, J. W., Hsiang, C. M., Cosgriff, T. M., Guang, M. Y., Smith, J. I., WU, Z. O., LeDuc, J. W., Zheng, Z. M., Meegan, J. M., Wang, Q. N., Oland, D. D., Gut, X. E., Glass, R H., Yuan, G. H., and Zhang, T. M., Prospective, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome, J. Infect. Dis. 164: 1119–1127 (1991).PubMedCrossRefGoogle Scholar
  41. 39.
    Huggins, J. W., Kim, G. R., Brand, O. M., and Mckee, K. T., JR., Ribavirin therapy for Hantaan virus infection in suckling mice, J. Infect. Dis. 153: 489–497 (1986).PubMedCrossRefGoogle Scholar
  42. 40.
    Hung, T., Xia, S.-M., Song, G., Liao, H.-X., Chao, T.-X., Chou, Z.-Y., and Hang, C.-S., Viruses of classical and mild forms of haemorrhagic fever with renal syndrome isolated in China have similar Bunyavirus-like morphology, Lancet 1: 589–591 (1983).PubMedGoogle Scholar
  43. 41.
    Hung, T., Xia, S. M., Zhao, T-X., Zhao, J. Y., Song, G., Liao, G. X. H., YE, W. W., Chu, Y. L., and Hang, C. S., Morphological evidence for identifying the viruses of hemorrhagic fever with renal syndrome as candidate members of the bunyaviridae family, Arch. Virol. 78: 137–144 (1983).PubMedCrossRefGoogle Scholar
  44. 42.
    Jiang, Y., Li, Z., and Song, G., Seroepidemiologic study of epidemic hemorrhagic fever with renal syndrome in China, Chin. Med. J. 94: 221–228 (1981).PubMedGoogle Scholar
  45. 43.
    Kitamura, T., Morita, C., Komatsu, T., Sugiyama, K., Arikawa, J., Shiga, S., Takeda, H., Aka°, Y., Imaizumi, K., Oya, A., Hashimoto, N., and Urasawa, S., Isolation of virus causing hemorrhagic fever with renal syndrome (Hfrs) through a cell culture system, Jpn. J. Med. Sci. Biol. 36: 17–25 (1983).PubMedGoogle Scholar
  46. 44.
    Kurata, T., Tsai, T. F., Bauer, S. P., McCormick, J. B., Immunofluoresence studies of disseminated Hantaan virus infection of sucking mice, Infect. Immun. 41: 391–398 (1983).PubMedGoogle Scholar
  47. 45.
    Lahdevirta, J., Nephropathia epidemica in Finland, a clinical, histological and epidemiological study, Ann. Clin. Res. 3 (Suppl. 8): 1–154 (1971).PubMedGoogle Scholar
  48. 46.
    Lahdevirta, L., Savola, J., Brummer-Korvenkontio, M., Berndt, R., Illikainen, R., and Vaheri, A., Clinical and serological diagnosis of nephropathia epidemica, the mild type of haemorrhagic fever with renal syndrome, J. Infect. 9: 230–238 (1984).PubMedCrossRefGoogle Scholar
  49. 47.
    LeDuc, J. W., Antoniades, A., and Siampoulos, K., Epidemiological investigations following an outbreak of hemorrhagic fever with renal syndrome in Greece, Am. J. Trop. Med. Hyg. 35: 654–659 (1986).PubMedGoogle Scholar
  50. 48.
    LeDuc, J. W., Childs, J. E., and Glass, G. E., The Hanta-viruses, etiologic agents of hemorrhagic fever with renal syndrome: A possible cause of hypertension and chronic renal disease in the United States, Annu. Rev. Public Health 13: 79–98 (1992).PubMedCrossRefGoogle Scholar
  51. 49.
    LeDuc, J. W., Ksiazek, T. G., Rossi, C. A., and Dalrymple, J. M., A retrospective analysis of sera collected by the hemorrhagic fever commission during the Korean Conflict, J. Infect. Dis. 162: 1182–1184 (1990).PubMedCrossRefGoogle Scholar
  52. 50.
    LeDuc, J. W., Smith, G. A., Childs, J. E., Pinheiro, F. R, Maiztegui, J. I., Niklasson, B., Antoniades, A., Robinson, D. M., Khin, M., Shortridge, K. E, Wooster, M. T., Elwell, M. R., Ilbery, P. L. T., Koech, D., Rosa, E. S. T., and Rosen, L., Global survey of antibody to Hantaan-related viruses among peridomestic rodents, Bull. WHO 64: 139–144 (1986).PubMedGoogle Scholar
  53. 51.
    Leduc, J. W., Smith, G. A., and Johnson, K. M., Hantaan-like viruses from domestic rats captured in the United States, Am. J. Trop. Med. Hyg. 33: 992–998 (1984).PubMedGoogle Scholar
  54. 52.
    LeDuc, J. W., Smith, G. A., Macy, M., and Hay, R. J., Certified cell lines of rat origin appear free of infection with Hantavirus, J. Infect. Dis. 152: 1082–1083 (1985).PubMedCrossRefGoogle Scholar
  55. 53.
    LeDuc, J. W., Smith, G. A., Pinheiro, F. P., Vasconcelso, P. E. C., Rosa, E. S. T., and Maiztegui, J. I., Isolation of a Hantaanrelated virus from Brazilian rats and serologic evidence of its widespread distribution in South America, Am. J. Trop. Med. Hyg. 34: 810–815 (1985).PubMedGoogle Scholar
  56. 53a.
    Lee, H. W., Hemorrhagic fever with renal syndrome in Korea, Rev. Infect. Dis. ll(Suppl. 4.): 5864–876 (1989).Google Scholar
  57. 54.
    Lee, H. W., Ahn, C. N., Song, J. W., Bask, L. J., Seo, T. J., and Park, S. C., Field trail of an inactivated vaccine against hemorrhagic fever with renal syndrome in humans, Arch. Virol. (Suppl. 1 ): 35–47 (1990).Google Scholar
  58. 55.
    Lee, H. W., Baek, L. J., and Doo, C. D., The study on breeding season of Apodemus agrarius, the natural host of Korean hemorrhagic fever, Korean J. Virol. 11: 1–5 (1981).Google Scholar
  59. 56.
    Lee, H. W., Baek, L. J., and Johnson, K. M., Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats, J. Infect. Dis. 146: 638–644 (1982).PubMedCrossRefGoogle Scholar
  60. 57.
    Lee, H. W., and Johnson, K. M., Laboratory-acquired infections with Hantaan virus, the etiologic agent of Korean hemorrhagic fever, J. Infect. Dis 146: 645–651 (1982).PubMedCrossRefGoogle Scholar
  61. 58.
    Lee, H. W., Lee, P. W., and Bask, L. J., Korean hemorrhagic fever IV. Serologic diagnosis, Korean J. Virol. 10: 7–13 (1980).Google Scholar
  62. 59.
    Lee, H. W., Lee, P. W., Bask, L. J., Song, C. K., and Seong, I. W., Intraspecific transmission of Hantaan virus, etiologic agent of Korean hemorrhagic fever, in the rodent Apodemus agrarius, Am. J. Trop. Med. Hyg. 30: 1106–1112 (1981).PubMedGoogle Scholar
  63. 60.
    Lee, H. W., Lee, R W., and Johnson, K. M., Isolation of the etiologic agent of Korean hemorrhagic fever, J. Infect. Dis. 137: 298–308 (1978).PubMedCrossRefGoogle Scholar
  64. 61.
    Lee, H. W., Lee, P. W., Lahdevirta, J., and Brummerkorvenkontio, M., Aetiological relation between Korean haemorrhagic fever and nephropathia epidemica, Lancet 1: 186–187 (1979).PubMedGoogle Scholar
  65. 62.
    Lee, H. W., Lee, P-W., Tamura, M., Tamura, T., and Okuno, Y., Etiological relation between Korean hemorrhagic fever and epidemic hemorrhagic fever in Japan, Biken J. 22: 41–45 (1979).PubMedGoogle Scholar
  66. 63.
    Lee, H. W., Park, D. H., Bask, L. J., Choi, K. S., Whang, Y. N., and Woo, M. S., Korean hemorrhagic fever patients in urban areas of Seoul, Korean J. Virol. 10: 1–6 (1980).Google Scholar
  67. 64.
    Lee, H. W., Seong, I. W., Bask, L. J., McLeod, D. A., Seo, J. S., and Kang, C. Y., Positive serological evidence that Hantaan virus, the etiologic agent of hemorrhagic fever with renal syndrome, is endemic in Canada, Can. J. Microbiol. 30: 1137–1140 (1984).PubMedCrossRefGoogle Scholar
  68. 65.
    Lee, P. W., Amyx, H. L., Yanagihara, R., Gajdusek, D. C., Goldgarber, D., and Gibbs, C. J., JR., Partial characterization of Prospect Hill virus isolated from meadow voles in the United States, J. Infect. Dis. 152: 826–829 (1985).PubMedCrossRefGoogle Scholar
  69. 66.
    Lee, P-W., Gibbs, C. J., JR., Gajdusek, D. C., and Yanagibara, R., Serotype classification of hantaviruses by indirect immunofluorescent antibody and plaque reduction neutralization tests, J. Clin. Microbiol. 22: 940–944 (1985).PubMedGoogle Scholar
  70. 67.
    Lee, R-W., Svedmyr, A., Gajdusek, D. C., and Yanagihara, R., Antigenic difference between European and East Asian viruses causing haemorrhagic fever with renal syndrome, Lancet 2: 256–257 (1981).PubMedGoogle Scholar
  71. 68.
    Lee, P. W., Yanagihara, R., Gibbs, C. J., JR., and Gajdusek, D. C., Pathogenesis of experimental Hantaan virus infection in laboratory rats, Arch. Virol. 88: 57–66 (1986).PubMedCrossRefGoogle Scholar
  72. 69.
    Linderholm, M., Billstrom, A., Settergren, B., and Tarnvbc, A., Pulmonary involvement in nephropathia epidemica as demonstrated by computed tomography, Infection 20: 263–266 (1992).PubMedCrossRefGoogle Scholar
  73. 70.
    Lloyd, G., and Jones, N., Infection of laboratory workers with hantavirus acquired from immunocytomas propagated in laboratory rats, J. Infect. 12: 117–125 (1986).PubMedCrossRefGoogle Scholar
  74. 71.
    Martin, M. L., Lindsey-Regnery, H., Sasso, D.R., Mccormick, J. B., and Palmer, E., Distinction between Bunyaviridae genera by surface structure and comparison with Hantaan virus using negative strain electron microscopy, Arch. Virol. 86: 17–28 (1985).PubMedCrossRefGoogle Scholar
  75. 72.
    Matsumoto, Y., Nishino, K., and Yagura, T., A case of suspicious epidemic hemorrhagic fever, Biken J. 7: 95–106 (1964).PubMedGoogle Scholar
  76. 73.
    Mccormick, J. B., Sasso, D. R., Palmer, E. L., and Kiley, M. R, Morphological identification of the agent of Korean haemorrhagic fever (Hantaan virus) as a member of the Bunyaviridae, Lancet 1: 765–768 (1982).PubMedCrossRefGoogle Scholar
  77. 73a.
    Mckee, K. T., JR., LeDuc, J. W., Macdonald, C., and Peters, C. J., Hemorrhagic fever with renal syndrome-A clinical perspective. Mil . Med. 150: 640–647 (1985).PubMedGoogle Scholar
  78. 74.
    Meegan, J. M., and LeDuc, J. W., Enzyme immunoassays, in: Manual of haemorrhagic fever with renal syndrome (H. W. Lee and J. M. Dalrymple, Eds.), pp. 83–88, World Health Organization, Seoul, Korea, 1989.Google Scholar
  79. 75.
    Montagnac, R., Schillinger, F., Croix, J. C., and Dournon, E., Fievre hemorrhagique avec syndrome renal du au virus Puumala: Deux cas avec hypertriglyceridemia dans le departement de l’Aube, Presse Med. 14: 2016–2017 (1985).PubMedGoogle Scholar
  80. 76.
    Morita, C., Matsuura, Y., Morikawa, S., and Kitamura, T., Age-dependent transmission of hemorrhagic fever with renal syndrome (Hfrs) virus in rats, Arch. Virol. 85: 145–149 (1985).PubMedCrossRefGoogle Scholar
  81. 77.
    Morita, C., Sugiyama, K., Matsuura, Y., Kitamura, T., Komatsu, T., Akao, Y, Jitsukawa, W., and Sakkakibara, H., Detection of antibody against hemorrhagic fever with renal syndrome (Hfrs) virus in sera of house rats captured in port areas of Japan, Jpn. J. Med. Sci. Biol. 36: 55–57 (1983).PubMedGoogle Scholar
  82. 78.
    Myasnikov, Y. A., Rezapkin, G. V., Shikova, Z. V., Tkachenko, E. A., Ivanova, A. A., Nurgaleeva, R. G., Stepanenko, A. G., Vereschagin, N. N., Loginov, A. I., Bagan, R. N., Zaitseva, A. A., Levacheva, Z. A., Bobylkova, T.V., Ishcheryakova, A. M., and Boruta, V. V., Antibodies to the Hfrs virus in the human population of European Rsfsr as detected by radioimmunoassay, Arch. Virol. 79: 109–115 (1984).PubMedCrossRefGoogle Scholar
  83. 79.
    Myhrman, G., Nephropathia epidemica, a new infectious disease in Northern Scandinavia, Acta Med. Scand. 140: 52–56 (1951).PubMedCrossRefGoogle Scholar
  84. 80.
    Nakamura, T., Yanagihara, R., Gibbs, C. J., JR., and Gajdusek, D. C., Immune spleen cell-mediated protection against fatal Hantaan virus infant mice, J. Infect. Dis. 151: 691–697 (1985).PubMedCrossRefGoogle Scholar
  85. 81.
    Nichol, S. T., Spiropoulou, C. F., Morzunov, S., Rollin, R E., Ksiazek, T. G., Feldman, H., Sanchez, A., Childs, J., Zaki, S., and Peters, C. J., Genetic identification of hanatavirus associated with an outbreak of acute respiratory illness, Science 262: 914–917.Google Scholar
  86. 82.
    Niklasson, B., Hornfeldt, B., Mullaart, M., Settergren, B., Tkachenko, E., Myasnikov, Y. A., Ryltceva, E. V., Leschinskaya, E., Malkin, A., and Dzagurova, T., An epidemiologic study of hemorrhagic fever with renal syndrome in Bashkirtostan (Russia) and Sweden, Am. J. Trop. Med. Hyg. 48: 670–675 (1993).PubMedGoogle Scholar
  87. 83.
    Niklasson, B., and LeDuc, J. W., Isolation of nephropathia epidemica agent in Sweden, Lancet 1: 1012–1013 (1984).PubMedCrossRefGoogle Scholar
  88. 84.
    Niklasson, B., and LeDuc, J. W., Epidemiology of nephropathia epidemica in Sweden, J. Infect. Dis. 155: 269–276 (1987).PubMedCrossRefGoogle Scholar
  89. 85.
    Niklasson, B., Leduc, J. W., Nystrom, K., and Nyman, L., Nephropathia epidemica: Incidence of clinical cases and antibody prevalence in an endemic area of Sweden, Epidemiol. Infect. 99: 559–562 (1987).PubMedCrossRefGoogle Scholar
  90. 86.
    Niklasson, B., Nyman, L., Linde, A., Grandien, M., and Dalrymple, J., An epidemiological survey of nephropathia epidemica in Sweden, Scand. J Infect. Dis. 15: 239–245 (1983).PubMedGoogle Scholar
  91. 87.
    Nerurkar, V. R., Song, K.-J., Gajdusek, D. C., and Yanagihara, R., Genetically distinct hantavirus in deer mice, Lancet 342: 1058–1059 (1993).PubMedCrossRefGoogle Scholar
  92. 88.
    NuzuM, E. O., Rossi, C. A., Stephenson, E. H., and LeDuc, J. W., Aerosol transmission of Hantaan and related viruses to laboratory rats, Am. J. Trop. Med. Hyg. 38: 636–640 (1988).Google Scholar
  93. 89.
    Okuno, Y., Yamaniski, K., Takahashi, Y., Tanishita, O., Nagai, T., Dantas, J. R., JR., Okamoto, Y., Tadano, M., and Takahashi, M., Haemagglutination-inhibition test for haemorrhagic fever with renal syndrome using virus antigen prepared from infected tissue culture fluid, J. Gen. Virol. 67: 149–156 (1986).PubMedCrossRefGoogle Scholar
  94. 90.
    Pensiero, M. N., Sharefkin, J. B., Dieffenbach, C. W., and Hay, J., Hantaan virus infection of human endothelial cells, J. Viml. 66: 5929–5936 (1992).Google Scholar
  95. 91.
    Penttinen, K., Lahdevirta, J., Kekomaki, R., Ziola, B., Salmi, A., Hautanen, A., Linstrom, P., Vaheri, A., Brummerkorvenkontio, M., and Wager, W., Circulating immune complexes, immunoconglutinins, and rheumatoid factors in nephropathia epidemica, J. Infect. Dis. 143: 15–21 (1983).CrossRefGoogle Scholar
  96. 92.
    RuBini, M. E., Jablon, S., and Mcdowell, M. E., Renal residuals of acute epidemic hemorrhagic fever, Arch. Intern. Med. 106: 378–387 (1960).CrossRefGoogle Scholar
  97. 93.
    Schmaljohn, C. S., and Dalrymple, J. M., Analysis of Hantaan virus Rna: Evidence for new genus of Bunyaviridae, Virology 131: 482–491 (1983).PubMedCrossRefGoogle Scholar
  98. 94.
    Schmaljohn, C. S., Hasty, S. E., and Dalrymple, J. M., Preparation of candidate vaccinia-vectored vaccines for haemorrhagic fever with renal syndrome, Vaccine 10: 10–13 (1992).PubMedCrossRefGoogle Scholar
  99. 95.
    Schmaljohn, C. S., Hasty, S. E., Dalrymple, J. M., LeDuc, J. W., Lee, H. W., Von Bonsdorf, C.-H., Brummer-Korvenkontio, M., Vaheri, A., Tsai, T. F., Regnery, H. L., Goldgaber, D., and Lee, P.-W., Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome, Science 227: 1041–1044 (1985).PubMedCrossRefGoogle Scholar
  100. 96.
    Schmaljohn, C. S., Hasty, S. E., Harrison, S. A., and Dalrymple, J. M., Characterization of Hantaan virions, the prototype virus of hemorrhagic fever with renal syndrome, J. Infect. Dis. 148: 1005–1012 (1983).PubMedCrossRefGoogle Scholar
  101. 97.
    Schmaljohn, C. S., Hasty, E., Rasmussen, L., and Dalrymple, J. M., Hantaan virus replication: Effects of monensin, tunicamycin and endoglycosidase on the structural glycoprotein, J. Gen. Virol. 67: 707–717 (1986).PubMedCrossRefGoogle Scholar
  102. 98.
    Settergren, B., Nephropathia epidemica (hemorrhagic fever with renal syndrome) in Scandinavia, Rev. Infect. Dis. 13: 736–744 (1991).PubMedCrossRefGoogle Scholar
  103. 99.
    Settergren, B., Juto, P., Wadel, G., Trollfors, B., and Norrby, S. R., Incidence and geographic distribution of serologically verified cases of nephropathia epidemica in Sweden, Am. J. Epidemiol. 127: 801–807 (1988).PubMedGoogle Scholar
  104. 100.
    Settergren, B., Leschinskaya, E., Zagidullin, I., Fazlyeva, R., Khunafina, D., and Niklasson, B., Hemorrhagic fever with renal syndrome: Comparison of clinical course in Sweden and in the Western Soviet Union, Scand. J. Infect. Dis. 23: 549–552 (1991).PubMedCrossRefGoogle Scholar
  105. 101.
    Sheedy, J. A., Froeb, H. F., Batson, H. A., Conley, C. C., Murphy, J. P., Hunter, R. B., Cugell, D. W., Giles, R. B., Bershadsky, S. C., Vester, J. W., and Yoe, R. H., The clinical course of epidemic hemorrhagic fever, Am. J. Med. 16: 619–628 (1954).PubMedCrossRefGoogle Scholar
  106. 102.
    Smorodinstsev, A. A., Chudadov, V. G., and Churilov, A. V., Haemorrhagic Nephroso-nephritis, Pergamon Press London, 1959.Google Scholar
  107. 103.
    Sommer, A. I., Traavik, T., Mehl, R., Berdahl, B. P., and Dalrymple, J. M., Reservoir animals for nephropathia epidemica in Norway: Indications of a major role for the bank vole (C. glareolus) in comparison with the woodmouse (A. sylvaticus), J. Hyg. 94: 123–127 (1985).PubMedCrossRefGoogle Scholar
  108. 104.
    Song, G., Hang, C.-S., Liao, H.-X., and Fu, J.-L., Antigenic comparison of virus strains of mild and classical types of epidemic haemorrhagic fever isolated in China and adaptation of these to cultures of normal cells, Lancet 1: 677–678 (1984).PubMedGoogle Scholar
  109. 105.
    Song, G., Hang, C., Liao, H., Fu, J., Gao, G., QIu, H. and Zhang, Q., Antigenic differences between viral strains causing classical and mild types of epidemic hemorrhagic fever with renal syndrome in China, J. Infect. Dis. 150: 889–894 (1984).PubMedCrossRefGoogle Scholar
  110. 106.
    Sugiyama, K., Matsuura, Y., Morita, C., Shiga, S., Akao, Y., Komatsu, T., and Kitamura, T., An immune adherence assay for discrimination between etiologic agents of hemorrhagic fever with renal syndrome, J. Infect. Dis. 149: 67–73 (1984).PubMedCrossRefGoogle Scholar
  111. 107.
    Svedmyr, A., Lee, P.-W., Goldgaber, D., Yanagihara, R., Gajdusek, D. C., Gibbs, C. J., JR., and Nystrom, K., Antigenic differences between European and East Asian strains of Hfrs virus, Scand. J. Infect. Dis. (Suppl.) 36: 86–87 (1982).Google Scholar
  112. 108.
    Takenaka, A., Gibbs, C. J., JR., and Gajdusek, D. C., Antiviral neutralizing antibody to Hantaan virus as determined by plaque reduction technique, Arch. Virol. 84: 197–206 (1985).PubMedCrossRefGoogle Scholar
  113. 109.
    Taller, A. M., Xiao, S.-Y., Godec, M. S., Gligic, A., Avsiczupanc, T., Goldfarb, L. G., Yanagihara, R., and Asher, D. M., Belgrade virus, a cause of hemorrhagic fever with renal syndrome in the Balkans, is closely related to Dobrava virus of field mice, J. Infect. Dis. 168: 750–753 (1993).PubMedCrossRefGoogle Scholar
  114. 110.
    Tamura, M., Occurrence of epidemic hemorrhagic fever in Osaka city: First cases found in Japan with characteristic feature of marked proteinuria, Biken J. 7: 79–94 (1964).PubMedGoogle Scholar
  115. 111.
    Tanishita, O., Takahashi Y., Okuno, Y., Yamanishi, K., and Takahashi, M., Evaluation of focus reduction neutralization test with peroxidase-antiperoxidase staining technique for hemorrhagic fever with renal syndrome virus, J. Clin. Microbiol. 20: 1213–1215 (1984).PubMedGoogle Scholar
  116. 112.
    Tkachenko, E. A., Donets, M. A., Rezapkin, G. V., Dzagurova, T. K., Ivanov, A. P., Leshchinskaya, E. V., Reshetnikov, I., Drozkov, S. G., Slonova, R. A., and Somov, G. R, Serotypes of Hfrs (haemorrhagic fever with renal syndrome) virus in East European and Far Eastern U.S.S.R., Lancet 1: 863 (1982).PubMedCrossRefGoogle Scholar
  117. 113.
    Tkachenko, E. A., Dzagurova, T. K., Leshchinskaya, E. V., Zagidulin, I. M., Ustjugova, I. M., Gasanova, T. A., Rezapin, G. V., and Miasmikov, J. A., Serological diagnosis of haemorrhagic fever with renal syndrome in European region of U.S.S.R., Lancet 2: 1407 (1982).PubMedCrossRefGoogle Scholar
  118. 114.
    Tkachenko, E. A., Ivanov, A. R, Dzagurova, T. K., Donets, M. A., Rezapkin, G. V., Leschinskaya, E. V., Zatgiduljn, U. M., Ivanova, A. A., Stradukhin, O. V., Mustafin, N. M., and Savinova, T. I., Immunosorbent assays for diagnosis of haemorrhagic fever with renal syndrome, Lancet 2: 257–258 (1981).PubMedGoogle Scholar
  119. 115.
    Traavik, T., Sommer, A. I., Mehl, R., Berdahl, B. P., Stavem, K., Henderi, O. H., and Dalrymple, J., Nephropathia epidemica in Norway: Antigen and antibodies in rodent reservoirs and selected human populations, J. Hyg. 93: 139–146 (1984).PubMedCrossRefGoogle Scholar
  120. 116.
    TsAi, T. F., Hemorrhagic fever with renal syndrome: Mode of transmission, Lab. Anim. Sci. 37: 428–430 (1987).PubMedGoogle Scholar
  121. 117.
    Tsai, T. F., Bauer, S. P., McCoRmicK, J. B., and Kurata, T., Intracerebral inoculation of suckling mice with Hantaan virus, Lancet 1: 503–504 (1982).CrossRefGoogle Scholar
  122. 118.
    TsAI, T. E, Bauer, S. P., Sasso, D. R., Whitfield, S. G., Mccormick, J. B., Caraway, T. C., Mcfarland, L., Bradford, H., and Kurata, T., Serological and virological evidence of a Hantaan virus-related enzootic in the United States, J. Infect. Dis. 152: 126–144 (1985).CrossRefGoogle Scholar
  123. 119.
    TsAI, T. F., Tang, J. W., Hu, S. L., YE, K. L., Chou, G. L., and Xu, Z. Y., Hemagglutination-inhibiting antibody in hemorrhagic fever with renal syndrome, J. Infect. Dis. 150: 895–898 (1984).CrossRefGoogle Scholar
  124. 120.
    Umenai, T., Lee, P. W., Toyoda, T., Yoshinaga, K., Horiuchi, T., Lee, H. W., Saito, T., Hongo, M., Nobunaga, T., and Ishida, N., Korean haemorrhagic fever in staff in an animal laboratory, Lancet 1: 1314–1316 (1979).PubMedCrossRefGoogle Scholar
  125. 121.
    Van Der Groen, G., Piot, P., Desmyter, J., Piot, P., Colaert, J., Muylle, L., Tkachenko, E. A., Ivanov, A. R, Verhagen, R., and Van Ypersele DE Strihou, C., Seroepidemiology of Hantaan-related virus infections in Belgian populations, Lancet 2: 1493–1494 (1983).Google Scholar
  126. 122.
    Van Der Groen, G., Tkachenko, E. A. Ivanov, A. P., and Verhagen, R., Haemorrhagic fever with renal syndrome related virus in indigenous wild rodents in Belgium, Lancet 2: 110–111 (1983).PubMedCrossRefGoogle Scholar
  127. 123.
    Van Ypersele DE Strihou, C., Vandenbrouck, J. M., Levy, M., Doyen, C., Cosyns, J. R, Van Der Groen, G., and Desmy-Ter, J., Diagnosis of epidemic and sporadic interstitial nephritis due to Hantaan-like virus in Belgium, Lancet 2: 8365–8366 (1983).Google Scholar
  128. 124.
    Vasyuta, Y. S., The epidemiology of haemorrhagic fever with renal syndrome in the R.S.F.S.R., Zh. Mikrobiol. Epidemiol. Immun. 32: 49–56 (1961).Google Scholar
  129. 125.
    Whi, W. Y., and Wang, L. H., Epidemiologic study of Korean hemorrhagic fever, Korean U. Med. J. 17: 137–144 (1980).Google Scholar
  130. 126.
    White, J. D., Shirey, E G., French, G. R., Huggins, J. W., Brand, O. M., and Lee, H. W., Hantaan virus, aetiological agent of Korean haemorrhagic fever, has bunyaviridae-like morphology, Lancet 1: 768–771 (1982).PubMedCrossRefGoogle Scholar
  131. 127.
    World Health Organization, Haemorrhagic fever with renal syndrome, Russian Federation, Wkly. Epidemiol. Rec. 68: 189–191 (1993).Google Scholar
  132. 128.
    Xiao, S.-Y., Chu, Y.-K., Knauert, F. K., Lofts, R., Dalrymple, J. M., and LeDuc, J. W., Comparison of hantavirus isolates using a genus-reactive primer pair polymerase chain reaction, J. Gen. Virol. 73: 567–573 (1992).PubMedCrossRefGoogle Scholar
  133. 129.
    Xiao, S.-Y., Diglisic, G., Avsic-Zupanc, T., and LeDuc, J. W., Dobrava virus as a new hantavirus: Evidence by comparative sequence analysis, J. Med. Virol. 39: 152–155 (1993).PubMedCrossRefGoogle Scholar
  134. 130.
    Xiao, S.-Y., LeDuc, J. W., Chu, Y. K., and Schmaljohn, C. S., Phylogenetic analyses of virus isolates in the genus Hantavirus, family Bunyaviridae, Virology 198: 205–217 (1994).PubMedCrossRefGoogle Scholar
  135. 131.
    Xiao, S.-Y., Yanagihara, R., Godec, M. S., Eldadah, Z. A., Johnson, B. K., Gajdusek, D. C., and Asher, D. M., Detection of hantavirus Rna in tissues of experimentally infected mice using reverse transcriptase-directed polymerase chain reaction, J. Med. Virol. 33: 277–282 (1991).PubMedCrossRefGoogle Scholar
  136. 132.
    Xu, Z.-Y., Guo, C.-S., Wu, Y.-L., Zhang, X.-W., and Liu, K., Epidemiological studies of haemorrhagic fever with renal syndrome: Analysis of risk factors and mode of transmission, J. Infect. Dis. 152: 137–144 (1985).PubMedCrossRefGoogle Scholar
  137. 133.
    Yamanishi, K., Dantas, J. R., Takahashi, M., Yamanouchi, T., Domae, K., Kawamata, J., and Kurata, T., Isolation of hemorrhagic fever with renal syndrome (Hfrs) virus from a tumor specimen in a rat, Biken J. 26: 155–160 (1983).PubMedGoogle Scholar
  138. 134.
    Yamanishi, K., Tanisurra, O., Tamura, M., Asada, H., Kondo, K., Takagi, M., Yoshida, I., Konobe, T., and Fukai, K., Development of inactivated vaccine against virus causing hae- morrhagic fever with renal syndrome, Vaccine 6: 278–282 (1988).PubMedCrossRefGoogle Scholar
  139. 135.
    Yan, D., Gu, X., Wang, D., and Yang, S., Studies on immunopathogenesis in epidemic hemorrhagic fever. Sequential observations on activation of the first complement component in sera from patients with epidemic hemorrhagic fever, J. Immunol. 127: 1604–1067 (1981).Google Scholar
  140. 136.
    Yanagihara, R., Hantavirus infection in the United States: Epizootiology and epidemiology, Rev. Infect. Dis. 12: 449–457 (1990).PubMedCrossRefGoogle Scholar
  141. 137.
    Yanagihara, R., Amyx, H. L., and Gajdusek, D. C., Experimental infection with Puumala virus, the etiological agent of nephropathia epidemica, in bank voles (Clethrionomys glareolus), J. Virol. 55: 34–38 (1985).PubMedGoogle Scholar
  142. 138.
    Yanagihara, R., Gajdusek, D. C., Gibbs, C. J., JR., and Traub, R., Prospect Hill virus: Serological evidence for infection in mammalogists, N. Engl. J. Med. 310: 1325–1326 (1984).PubMedCrossRefGoogle Scholar
  143. 139.
    Yang, Y., Xs, Z. Y., Zhu, Z. Y., and Tsai, T. E, Isolation of haemorrhagic fever with renal syndrome virus from Suncus murinus, an insectivore, Lancet 1: 513–514 (1985).Google Scholar
  144. 140.
    Zhang, C. A., Xie, Y. J., Zhang, C. A., Mccormick, J. B., Sanchez, A., Engelman, H. M., Chen, S. Z., GU, X. S., Yang, W. T., and Zhang, J., New isolates of Hfrs virus in Sichuan, China and characterization of antigenic differences by monoclonal antibodies, Lancet 1: 84–93 (1986).Google Scholar

Suggested Reading

  1. Cosgriff, T. M. (ED.), Hemostatic impairment associated with hemorrhagic fever viruses, Rev. Infect. Dis. ll(Suppl. 4 ): S669–896 (1989).CrossRefGoogle Scholar
  2. Lahdevirta, J., Nephropathia epidemica in Finland, Am. J. Clin. Res. 3 (Suppl. 8): 1–154 (1971).Google Scholar
  3. Lahdevirta, J., Symposium on Epidemic Hemorrhagic Fever, Am. J. Med. 16: 619–709 (1954).CrossRefGoogle Scholar
  4. Trincseni, T., and Keleti, B., Clinical Aspects and Epidemiology of Haemorrhagic Fever with Renal Syndrome, Akademiai Kiado, Budapest, 1971.Google Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • James W. LeDuc
    • 1
  1. 1.National Center for Infectious DiseasesCenters for Disease Control and PreventionAtlantaUSA

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