Epithelial Tumors of the Thymus pp 305-314 | Cite as
Our Approach in the Preparation for Thymectomy in Myasthenia Gravis
Chapter
Abstract
Thymectomy, first performed by Sauerbruch in 1912, became a major treatment in myasthenia gravis although no prospective study of its value has ever been made (1–5). Since the first thymectomies, postoperative myasthenic crisis, has been one of the most important and feared postoperative complications, with a mortality rate ranging from 15%–33,3% in the 1950s to a current 3% (6–9).
Keywords
Intensive Care Unit Stay Myasthenic Crisis Bulbar Symptom Anticholinesterase Agent Impaired Respiratory Function
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References
- 1.Perlo VP, Poskenzer DD, Schwab RS, Viets H, Osserman KO, Genkins G. Myasthenia gravis: Evaluation of treatment in 1,355 patients. Neurology 1966; 16:431–442.PubMedCrossRefGoogle Scholar
- 2.Buckingham JM, Howard FM Jr, Bernatz PE. The value of thymectomy in myasthenia gravis: a computerassisted matched study. Ann Surg 1976; 184:453–458.PubMedCrossRefGoogle Scholar
- 3.Olanow CW, Wechsler AS, Sirotkiin-Roses M. Thymectomy as primary therapy in myasthenia gravis. Ann NY Acad Sci. 1987; 505:595–606.PubMedCrossRefGoogle Scholar
- 4.Papatestas AE, Genkins G, Kornfeld P, Eisenkraft JB, Fagerstrom RP, Pozner J, Aufses AH: Efects of thymectomy in Myasthenia Gravis. Ann Surg. 1987; 206: 79–88.PubMedCrossRefGoogle Scholar
- 5.Otto TJ, Strugalska H. Surgical treatment for myasthenia gravis. Thorax 1987; 42:199–204.PubMedCrossRefGoogle Scholar
- 6.Galofre M, Ponseti JM. Timectomia en la miastenia gravis. Barcelona Quirurgica 1971; 15:449–453.Google Scholar
- 7.Osserman KE. Myasthenia Gravis. Grune & Stratton. NY. 1958; 165-183.Google Scholar
- 8.Viets HR. Myasthenia Gravis. The second international symposium proceedings. Charles C Thomas Publisher, Bannerstone House, Springfiie, Illinois, USA. 1961; 637-652.Google Scholar
- 9.Molnár J, Szobor A. Myasthenia gravis: effect of thymectomy in 425 patients. A 15-year experience. Eur J Cardio-thorac Surg 1990; 4:8–14.CrossRefGoogle Scholar
- 10.Walker MB: Treatment of myasthenia gravis with physostigmine. Lancet 1934; 1: 1200–1201.CrossRefGoogle Scholar
- 11.Oosterhuis HJ. Observations of the natural history of myasthenia gravis an the efect of thymectomy. Ann NY Acad Sci 1981; 377: 678–690.PubMedCrossRefGoogle Scholar
- 12.Martens HG, Balzereit F, Leipert M. The treatment of severe myasthenia gravis with immunosuppressive agents. Eur Neurol 1969; 2:321–339.CrossRefGoogle Scholar
- 13.Ponseti JM, Galofre M. Prespectivas actuales en el tratamiento de la miastenia gravis. Med Clin (Barc) 1972; 58:308–313.Google Scholar
- 14.Mertens HG, Hertel G, Renther P, et al: Effect of immunosuppressive drugs(azathioprine). Ann NY Acad Sci 1981; 377: 691–699.PubMedCrossRefGoogle Scholar
- 15.Patrick J, Lindstrom J: Antiimmune response to acetylcholine receptor. Science 1973; 180:871–872.PubMedCrossRefGoogle Scholar
- 16.Dau PC, Lindstrom CK, Cassel CK, Denys EH, Shev EE, Spitler LE: Plasma pheresis and immunosuppessive drog therapy in myasthenia gravis. N Engl J Med 1977; 1134-1140.Google Scholar
- 17.Dau PC: Plasmapheresis and the Immunobiologi of Myasthenia Gravis. Houghton Mifflin, Boston 1979Google Scholar
- 18.Ponseti JM. Miastenia gravis y timoma. Rev Neurol. 1975; 3:279–287.Google Scholar
- 19.Ponseti JM, Plasmaferesis en el tratamiento de la miastenia gravis. Med Clin (Barc) 1983; 80: 121–122.Google Scholar
- 20.Gajdos P, Outin H, Elkharrat D, Brunei D, Rohan-Chabot P, Raphael JC, Goulon M, Goulon-Goeau C, Morel E: High-dose intravenous gammaglobulin for myasthenia gravis. Lancet 1984; 406-407.Google Scholar
- 21.Fateh-Moghadam A, Wick M, Besinger U, Geursen RG: High-dose Intravenous gammaglobulin for myasthenia gravis: Lancet 1984; 848-849.Google Scholar
- 22.Ippoliti G, Cosi V, Piccolo G, Lombardi G, Mantegaz R. High-dose intravenous gammaglobulin for myasthenia gravis. Lancet 1984; 2: 809.CrossRefGoogle Scholar
- 23.Devathasan G, Kneh YK, Chng PN. High-dose intravenous gammaglobulin for myasthenia gravis Lancet 1984;2:809–810.Google Scholar
- 24.Arsura EL, Bick A, Brunner G, Namba T, Grob D: High-dose intravenous immunoglobulin in the managment of myasthenia gravis: Arch Intern Med 1986; 146: 1365–1368.PubMedCrossRefGoogle Scholar
- 25.Bonaventura I, Ponseti J, Espanol T, Matias-Guiu J, Codina-Puiggros A. High-dose intravenous gammaglobulin therapy for myasthenia gravis. J Neurol 1987; 234: 363.CrossRefGoogle Scholar
- 26.Szobor A. Crises in Myasthenia Gravis. Hafner Publishing Company, NY. 1970; 39-42.Google Scholar
- 27.Grob D, Brunner NG, Namba T: The natural course of myasthenia gravis and effect of therapeutic measures. Ann NY Acad Sci 1981; 377: 652–669.PubMedCrossRefGoogle Scholar
- 28.Rodriguez M, Gomez MR, Howard FM, Taylor WF: Myasthenia gravis in children: long-term fallow-up. Ann Neurol 1983; 13: 504–510.PubMedCrossRefGoogle Scholar
- 29.Pradas J, Illa I, Tratamiento de la miastenia gravis: Sant Pau 1984; 5: 24–39.Google Scholar
- 30.Cooper JD, Al-Jilaihawa AN, Pearson FG, Humphrey JG, Humphrey HE. An improved Technique to facilitate transcervical thymectomy for myasthenia gravis. Ann Thorac Surg. 1988; 45:242–247.PubMedCrossRefGoogle Scholar
- 31.Mulder DG, Graves M, Herrmann C. Thymectomy for Myasthenia Gravis: Recent Observations and Comparisons With Past Experience. Ann Thorac Surg 1989; 48:551–555.PubMedCrossRefGoogle Scholar
- 32.Ponseti JM. Contribucion al estudio de la miastenia gravis. Valor de la espirometria como indice de recuperacion. Resumen de Tesis Doctoral. Universidad Autónoma de Barcelona, 1977Google Scholar
- 33.Jaretzki III J, Penn AS, Younger DS, Wolff M Olarte MR, Lovelace RE, Rowland LP, “Maximal” thymectomy for myasthenia gravis. J Thorac Cardiovasc Surg 1988; 95: 747–757.PubMedGoogle Scholar
- 34.Kornfeld P, Merav A, Fox S, Maier K. Haw reliable are imaging procedures in detectin residual thymus after previus thymectomy. Ann NY Acd Sci 1993; 681:575–576.CrossRefGoogle Scholar
- 35.Fischer JE, Grinvalski HT, Nussbaum MS, Sayers HJ, Cole RE, Samaha FJ. Aggressive surgical approach for drug-free remission from myasthenia gravis. Ann Surg 1987;205:496–503.PubMedCrossRefGoogle Scholar
- 36.Hankins JR, Maye RF, Satterfielt JR, Turney SZ, Attar S, Sequeira AJ, Thompson SW, McLaughlin JS. Thymectomy for myasthenia gravis: 14-year experience. Ann Surg 1985; 201:18–25.CrossRefGoogle Scholar
- 37.Olanow CW, Wechsler AS, Roses AD. A prospective study of thymectomy and serum acetylcholine receptor antibodies in myasthenia gravis. Ann Surg 1982; 196:113–121.PubMedCrossRefGoogle Scholar
- 38.Papatestas AE, Genkins G, Kornfeld P, Eisenkraft JB, Fagerstrom RP, Pozner J, Aufses AH. Effects of thymectomy in myasthenia gravis. Ann Surg 1987; 201:79–88.CrossRefGoogle Scholar
- 39.Kirschner PA. Myasthenia gravis and other parathymyc syndromes. Chest Sur Clin N A. 1992;2. 1. 183-201.Google Scholar
- 40.Simpson JA: Myasthenia gravis: A new hypothesis. Scott Med J. 1960; 5: 419–436.Google Scholar
- 41.Nastuk WL, Plescia OJ, Osserman KE: Changes in serum complement activity in patients with myasthenia gravis. Proc Soc Exp Biol Med 1960; 105: 177–184.PubMedCrossRefGoogle Scholar
- 42.Maggi G, Casadio C, Cavallo A, Cianci R, Molinatti M, Ruffini E. Thymectomy in myesthenia gravis: Resutls of 662 cases operated upon in 15 years. Eur J Cardio-thorac Surg. 1989; 3:504–511.CrossRefGoogle Scholar
- 43.Sato T, Nishimiya J, Arai K, Anno M, Yamawaki N, Kuroda T, Inagaki K. Selective removal of anti-acetylcholine receptor antibodies in sera patients with myasthenia gravis in vitro with a new immunosorbent. In: Oda T, ed. Therapeutic Plasmapheresis (III). Stuttgart-New York: Schattauer, 1983; 565-568Google Scholar
- 44.Heininger K, Gaczkowski A, Hartung HP Toyka KV, Borberg H. Plasma separation and imunoadsorption in myasthenia gravis. Therapeutic Plasmapheresis (V) Ed. Shattauer. 1985; 3-10.Google Scholar
- 45.Passalacqua S, Splendiani G, Sturniolo A, Costanzi S, Barbera G, Bartoccioni E, Evoli A, Scoppetta C, Adorno D, Di Guilio S, Casciani CU. Immunosorbent treatment in myasthenia gravis. Apheresis. Alan R. Lisslnc. 1990; 285-288.Google Scholar
- 46.Kawanami S, Mori S, Uchida T, Nagasawa H, Shirotani T, Naito S, Shibuya N. Therapeutic Plasmapheresis (IX) ICAOT Press. Cleveland. 1991; 318:167–171.Google Scholar
- 47.Avanzi G, Marconi G. Semiselective Immunoadsorption of Anti-AChR abs on TRyptophan Column in Myasthenia Gravis. Clinical Experience in 32 Patients. Transfus. Sci. 1993; 14:17–21.Google Scholar
- 48.Strieker RB, Kwiatkowska BJ, Habis JA, MacLeod DE, Kiprov DD. Response to plasmapheresis following failure of intravenous gammaglobulin in patients with Myasthenia Gravis and Guillain-Barre Syndrome. J Clin Apheresis 1993; 8: 733.Google Scholar
- 49.Ferrero B, Durelli I, Cavallo R, Dutto A, Aimo G, Pecchio F, Bergamasco B. Therapies for exacerbation of Myasthenia Gravis. The mechanism of action of intravenous high-dose immunoglobulin G. Ann NY Acd Sci 1993; 681:563–566.CrossRefGoogle Scholar
- 50.Arsura EL, Bick A, Bruner NG, Grob B. Effects of repeated doses of intravenous immunoglobulin in myasthenia gravis. Am J Med Sci 1988; 295:438–443.PubMedCrossRefGoogle Scholar
- 51.Fort JM, Ponseti JM. Altas dosis de globulina gamma intravenosa en el tratamiento de la miastenia gravis. Med Clin (Barc) 1988; 91:325–328.Google Scholar
- 52.Zweiman B. Theoretical mechanisms by which immunoglobulin therapy might benefit myasthenia gravis. Clin Immunol Immunopathol. 1989; 53: 83–91.CrossRefGoogle Scholar
- 52.Ponseti JM. Miastenia Gravis. Manual Terapéutico. Springer-Verlag Ibérica. Barcelona. 1995; 139-145.Google Scholar
- 54.Drachman DB. Myasthenia Gravis. N Engl J Med 1994; 330:1797–1810.PubMedCrossRefGoogle Scholar
- 55.Edan G, Landgraf F. Experience with intravenous immunoglobulin in myasthenia gravis: a review. J Neurol Neurosurg Psychiatry 1994;57(Supplement):55-56.Google Scholar
- 56.Strieker RB, Kwiatkowska BJ, Habis JA, Kiprov DD. Myasthenic Crisis: Response to Plasmapheresis following failure of intravenous γ-Globulin. Arch Neurol 1993; 50:837–840.CrossRefGoogle Scholar
- 57.Sanders DB, Scoppetta C. The treatment of patients with myasthenia gravis.In Myasthenia Gravis and Myasthenic Syndromes. Edited by Sanders DB. Neurologic Clinics 1994; 12:343-368Google Scholar
- 58.Blasczyk R, Westhoff U, Grosse-Wilde H: Soluble CD4, CD8, and HLA molecules in commercial immunoglobulin preparations. Lancet 1993; 341: 789–790.PubMedCrossRefGoogle Scholar
- 59.Lam L, Whitsett CF, McNicoll JM, Hodge TW, Hooper J: Immunologically active proteins in intravenous immunoglobulin. Lancet 1993; 342: 678.PubMedCrossRefGoogle Scholar
- 60.Ahlberg R, Yi Q, Pirskanen R, Martell G, Swerup C, Rieber P, Riethmuller G, Holm G, Lefvert AK. Clinical improvement of Myasthenia Gravis by treatment with a chimeric ant-CD4 monoclonal antibody. Ann NY Acd Scti 1993; 681:552–555.CrossRefGoogle Scholar
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