Th-1/Th-2 Switch Regulation in Immune Responses to Inhaled Antigens

Role of Dendritic Cells in the Aetiology of Allergic Respiratory Disease
  • P. G. Holt
  • C. Macaubas
  • D. Cooper
  • D. J. Nelson
  • A. S. Mcwilliam
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)

Abstract

Until comparatively recently, allergic (atopic) disease was viewed as a manifestation of hyperreactivity to essentially non-pathogenic soluble protein antigens which are ubiquitous in the natural environment. In this context, normality would equate to non-responsiveness, resulting from either tolerance or ignorance of the antigens. However, it is now clear (reviewed inc[1]) that active T cell immunity to at least one class of these antigens (airborne ”inhalant“ allergens) is essentially universal amongst adults, clinical reactivity being a function of the cytokine profiles of CD4+ Th-cells which dominate relevant Th-memory populations. Thus, atopics who respond to allergen exposure via IgE production, eosinophilia etc., manifest Th-2-skewed memory, whereas T cell memory in non-responsive normal adults is dominated by Th- I -cytokines such as IFNγ. The situation with respect to ingested environmental allergens (ubiquitous in the diet) appears both qualitatively and quantitatively different, as T cell reactivity to this class of antigens is considerably less frequent in the adult population1.2.

Keywords

Major Histocompatibility Complex Class Oral Tolerance Switch Regulation Inhalant Allergen Food Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • P. G. Holt
    • 1
  • C. Macaubas
    • 1
  • D. Cooper
    • 1
  • D. J. Nelson
    • 1
  • A. S. Mcwilliam
    • 1
  1. 1.Division of Cell BiologyTVW Telethon Institute for Child Health ResearchWest PerthAustralia

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