B7-2+ Low Density APCS are as Effective as B7-2− Small Resting B Cells in Inducing Specific Unresponsiveness to Minor Histocompatibility (miH) Antigen(S) in Vivo
Dendritic cells and small resting B cells are thought to be immunogenic and tolerogenic in the periphery, respectively, as dendritic cells but not resting B cells can provide costimulatory signal(s) (1–7). Fuchs and Matzinger demonstrated that resting B cells but not dendritic cells could induce tolerance to H-Y mismatched skin grafts (8). We have extended this study by comparing the ability of dendritic cells and resting B cells to induce tolerance to cardiac grafts mismatched for miH antigen(s).
KeywordsSkin Graft Costimulatory Signal Operational Tolerance Cardiac Graft John Radcliffe Hospital
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