Growth and Differentiation of Human Dendritic Cells from CD34+ Progenitors
Several groups originally established the importance of GM-CSF and TNFα in the generation of dendritic cells from CD34+ precursors (1–3), and most investigators have used cord blood as the starting source. Studies from our laboratories confirmed the essential role of these cytokines in supporting bone marrow CD34+-derived dendritic cell growth and differentiation, and the addition of c-kit-ligand facilitated more detailed phenotypic and functional characterization of the dendritic cell progeny than had previously been possible (4).
KeywordsDendritic Cell Cord Blood Human Dendritic Cell Bone Marrow Progenitor Cord Blood CD34
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