Langerhans Cells Require Signals from Both Tumour Necrosis Factor α and Interleukin 1β for Migration

  • M. Cumberbatch
  • R. J. Dearman
  • I. Kimber
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)

Abstract

Tumour necrosis factor α (TNF-α) is considered to play an important role in the initiation of epidermal Langerhans cell (LC) migration during the induction phase of cutaneous immune responses.1 Intradermal injection of mice with homologous recombinant TNF-α stimulates both the migration away from the epidermis of a proportion of LC and the subsequent accumulation in draining lymph nodes of dendritic cells (DC).2,3 Moreover, treatment of mice with a neutralizing anti-TNF-α antibody has been shown to inhibit markedly the increase in lymph node DC associated with exposure to skin sensitizing chemicals,4,5 ultraviolet B light,6 or the skin irritant sodium lauryl sulphate.4

Keywords

Drain Lymph Node Intradermal Injection Normal Rabbit Serum Dendritic Cell Migration Epidermal Sheet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    I. Kimber and M. Cumberbatch, Langerhans cell migration: initiation and regulation. In: The Immune Functions of Epidermal Langerhans cells. H. Moll (ed.), R.G. Landes Co., Austin pp 103 (1994).Google Scholar
  2. 2.
    M. Cumberbatch and I. Kimber, Dermal tumour necrosis factor-a induces dendritic cell migration and possibly provides one stimulus for Langerhans cell migration. Immunology 75: 257 (1992).PubMedGoogle Scholar
  3. 3.
    M. Cumberbatch, I. Fielding and I. Kimber, Modulation of epidermal Langerhans cell frequency by tumour necrosis factor-a. Immunology 81: 395 (1994).PubMedGoogle Scholar
  4. 4.
    M. Cumberbatch and I. Kimber, Tumour necrosis factor-a is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization. Immunology 84: 31 (1995).PubMedGoogle Scholar
  5. 5.
    B. Wang, S. Kondo, G.M. Shivji, H. Fujisawa, T.W. Mak and D.N. Sauder, Tumour necrosis factor receptor II (p75) signalling is required for the migration of Langerhans cells. Immunology 88: 284 (1996).PubMedCrossRefGoogle Scholar
  6. 6.
    A.M. Moodycliffe, I. Kimber and M. Norval, Role of tumour necrosis factor-a in ultraviolet-induced dendritic cell migration and suppression of contact hypersensitivity. Immunology 81: 79 (1994).PubMedGoogle Scholar
  7. 7.
    A.H. Enk and S.I. Katz, Early molecular events in the induction phase of contact sensitivity. Proc. Natl. Acad. Sci. USA 89: 1398 (1992).PubMedCrossRefGoogle Scholar
  8. 8.
    C. Heufler, G. Topar, F. Koch, B. Trockenbacher, E. Kampgen, N. Romani and G. Schuler. Cytokine gene expression in murine epidermal cell suspensions. Interleukin 113 and macrophage inflammatory protein la are selectively expressed in Langerhans cells but are differentially regulated in culture. J. Exp. Med. 176: 1221 (1992).PubMedCrossRefGoogle Scholar
  9. 9.
    A.H. Enk, V.L. Angeloni, M.C. Udey and S.I. Katz, An essential role for Langerhans cell-derived IL-113 in the initiation of primary immune responses in skin. J. Immunol. 150: 3698 (1993).PubMedGoogle Scholar
  10. 10.
    L.P. Shornick, P. De Togni, S. Mariathasan, J. Goellner, J. Strauss-Schoenberger, R.W. Karr, T.A. Ferguson and D.D. Chaplin, Mice deficient in IL-1(3 manifest impaired contact hypersensitivity to trinitrochlorobenzene. J. Exp. Med. 183: 1427 (1996).PubMedCrossRefGoogle Scholar
  11. 11.
    M. Cumberbatch, R.J. Dearman and I. Kimber, Stimulation of Langerhans cell migration in mice by tumour necrosis factor-a and interleukin 113. In: Dendritic Cells in Fundamantal and Clinical Immunology. Vol.3, P. Ricciardi-Castagnoli (ed.), Plenum Press, New York pp (this volume).Google Scholar
  12. 12.
    A. Rambukkana, F.H.M. Pistoor, J.D. Bos, M.L. Kapsenberg and P.K. Das, Effects of contact allergens on human Langerhans cells in skin organ culture: migration, modulation of cell surface molecules, and early expression of interleukin 113 protein. Lab. Invest. 74: 422 (1996).PubMedGoogle Scholar
  13. 13.
    N.S. Trede, R.S. Geha and T. Chatila, Transcriptional activation of IL-113 and tumour necrosis factor a genes by MHC class II ligands. J. Immunol. 146: 2310 (1991).PubMedGoogle Scholar
  14. 14.
    B. Ryffel, M. Brockhaus, B. Greiner, M.J. Mihatsch and F. Gudat, Tumour necrosis factor receptor distribution in human lymphoid tissue. Immunology 74: 446 (1991).PubMedGoogle Scholar
  15. 15.
    A. Larregina, A. Morelli, E. Kolkowski and L. Fainboim, Flow cytometric analysis of cytokine receptors on human Langerhans cells. Changes observed after short-term culture. Immunology, 87: 317 (1996).PubMedCrossRefGoogle Scholar
  16. 16.
    M. Cumberbatch, S.W. Peters, S.J. Gould and I. Kimber, Intercellular adhesion molecule-1 (ICAM-1) expression by lymph node dendritic cells: comparison with epidermal Langerhans cells. Immunol. Lett. 32: 105 (1992).PubMedCrossRefGoogle Scholar
  17. 17.
    K. Schwarzenberger and M.C. Udey, Contact allergens and epidermal proinflammatory cytokines modulate Langerhans cell E-cadherin expression in situ. J. Invest. Dermatol. 106: 553 (1996).PubMedCrossRefGoogle Scholar
  18. 18.
    D.I. Gabrilovich, G.M. Ward, S. Patterson, J.J. Harvey and S.C. Knight, Retrovirus-induced immunosuppression via blocking of dendritic cell migration and down-regulation of adhesion molecules. Immunology 82: 82 (1994)PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • M. Cumberbatch
    • 1
  • R. J. Dearman
    • 1
  • I. Kimber
    • 1
  1. 1.Zeneca Central Toxicology LaboratoryMacclesfield CheshireUK

Personalised recommendations