Migration of Cultured Chimpanzee Dendritic Cells Following Intravenous and Subcutaneous Injection
In recent years much interest has been generated in using dendritic cells as vehicles for cancer immunotherapy1. This interest is based on the fact that dendritic cells function as specialized immunostimulatory cells in vivo, serving as initiators of T cell immune responses to antigen2. The dendritic cell-based approach to immunotherapy is feasible because of two advances: the identification and isolation of specific human tumor-associated antigens, and the development of techniques to propagate dendritic cells in vitro from precursor cells3,4. Hence, it is now possible to grow large numbers of dendritic cells from a patient’s blood or bone marrow in vitro, treat these cells with tumor-associated antigens, and administer to the donor with the aim of inducing a strong and therapeutic immune response to the tumor. The therapeutic efficacy of the technique has been tested in murine tumor models5, and clinical trials in cancer patients are being initiated6.
KeywordsDendritic Cell Drain Lymph Node Inguinal Lymph Node Immunotherapy Protocol Yerkes Regional Primate Research
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