Human Calcitonin Administered by the Nasal Route: Bioavailability of Different Formulations and Efficacy in Post-Menopausal Osteoporosis

  • A. E. Pontiroli
  • M. Alberetto
  • A. Calderara
  • E. Pajetta
  • V. Manganelli
  • L. Tessari
  • G. Pozza
Part of the NATO ASI Series book series (NSSA, volume 125)

Abstract

After its discovery by Copp et al. in 1962, calcitonin has been employed in the management of several bone diseases, for instance postmenopausal osteoporosis and Paget’s disease. Treatment of the above disease requires i.m. or s.c. administrations daily or on alternate days for prolonged periods, and this can reduce patient compliance during the course of the disease (Stevenson et al., 1981).

Keywords

Postmenopausal Osteoporosis Intranasal Administration Salmon Calcitonin Spray Solution Human Calcitonin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Austin L. A., and Heat H., 1981, Calcitonin., New Engl. Med. J., 304: 269.CrossRefGoogle Scholar
  2. Copp D. H., Cameron B. A., Cheney B. A., Davidson A. G. F., and Henze K. G., 1962, Evidence for calcitonin: a new hormone from the parathyroid that lowers blood calcium, Endocrinology, 70: 638.PubMedCrossRefGoogle Scholar
  3. Heerse J. N. M., Marcus R., and Aurbach G. D., 1974, Calcitonin and formation of 3′5′-AMP in bone and kidney., Endocrinology, 94: 241.CrossRefGoogle Scholar
  4. Pontiroli A. E., Alberetto M., and Pozza O., 1985, Intranasal calcitonin and plasma calcium concentrations in normal subjects., Brit. Med. Journal, 290:1390.CrossRefGoogle Scholar
  5. Reginster J. Y., Albert A., and Franchimont P., 1985, Salmon calcitonin nasal spray in Paget’s disease of bone. Calcified Tissue International, 37: 577.PubMedCrossRefGoogle Scholar
  6. Ziegler R., Holz G., Raue F., and Streibl W., 1979, Nasal application of human calcitonin in Paaet’s disease of bone., Mol. Endocrinoi. 1: 293.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • A. E. Pontiroli
    • 1
  • M. Alberetto
    • 1
  • A. Calderara
    • 1
  • E. Pajetta
    • 1
  • V. Manganelli
    • 1
  • L. Tessari
    • 1
  • G. Pozza
    • 1
  1. 1.Istituto Scientifico Ospedale San Raffaele, Clinica Medica and Clinica OrtopedicaUniversita’ di MilanoMilanoItaly

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