Biopharmaceutical Aspects on the Intranasal Administration of Peptides
The intranasal route for administering peptides is probably one of the most neglected methods of delivery to the systemic circulation. Yet because of its high surface area available for absorption, its highly vasculized bed of mucosa and the fact that the nasal cavity appears to have very little metabolizing capacity all indicate that absorption across the nasal membranes is a reasonable proposition. The increasing importance which has been attached to peptides as new therapeutic agents is a consequence of the isolation and structural characterisation of various peptides, including the discovery of hypothalamic releasing hormones and pituitary hormones. The advantages of the naturally occuring peptide hormones as drug candidates have mainly been attributed to their potent pharmacological activity and their good biological tolerance. However, the disadvantages have been their broad pharmacological activity (which is often masked by a singular potent effect) and their relative short biological halflife (Table 1).
KeywordsNasal Cavity Diabetes Insipidus Nasal Spray Nasal Administration Intranasal Route
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