Methodology for Simulation of Metabolic Pathways and Calculation of Control Coefficients
The main advantage of metabolic control theory is that it is not necessary to consider enzyme kinetic mechanisms for an experimental analysis of real biochemical systems. Control coefficients can be directly determined by measuring the system response to a small perturbation of some external parameter. This can be accomplished without any knowledge of the kinetic model; the only requirement is that the system response may be measured.
KeywordsRate Equation Microscopic Model External Parameter Macroscopic Model Elasticity Coefficient
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- Kubicek, M. & Marek, M. (1983) in Computational Methods in Bifurcation Theory and Dissipative Structures (Cabannes, M., Holt, M., Keller, H. B., Killen, J. & Orszag, S. A., eds.), pp. 87–90, Springer-Verlag, NewYorkGoogle Scholar