Control of Breathing and Its Modeling Perspective pp 303-306 | Cite as
Developmental Aspects of the Central Effects of Hypoxia
Abstract
Although several hypotheses have been proposed1-3, the mechanisms of the hypoxic depression of breathing in newborns are still not well understood. A more recent study shows that the drop in ventilation coincides with a decrease in metabolic rate in newborns of several mammalian species4. These parallel effects imply that hypoxia does not abolish the homeostatic link between ventilation and metabolism. Nevertheless, central hypoxia could limit influences of the suprapontine structures on different control systems. These influences are independent of chemical stimuli and, via the reticular activating system (RAS), modify excitability of the respiratory neurones5, 6. Peripheral nerve stimulation has comparable effects to the direct stimulation of the RAS, i. e. shortening of expiration and an increase in phrenic activity in newborn7 and adult animals6.
Keywords
Vagal Stimulation Respiratory Effect Peripheral Nerve Stimulation Central Hypoxia Respiratory NeuronePreview
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References
- 1.K. Iversen, T. Hedner and P. Lundberg. GABA concentration and turn-over in neonatal rat brain during asphyxia and recovery. Acta Physiol. Scand. 118:91 (1983).PubMedCrossRefGoogle Scholar
- 2.H.R. Winn, R. Rubio and R.M. Berne. Brain adenosine concentration during hypoxia in rats. Am. J. Physiol. 241 (Heart Circ. Physiol. 10):H235 (1981).PubMedGoogle Scholar
- 3.R.L. Martin-Body and B.M. Johnston. Central origin of the hypoxic depression of breathing in the newborn Respir. Physiol. 71:25 (1988).PubMedCrossRefGoogle Scholar
- 4.J.P. Mortola, R. Rezzonico and C. Lanthier. Ventilation and oxygen consumption during acute hypoxia in newborn mammals: a comparative study. Respir. Physiol. 78:31 (1989).PubMedCrossRefGoogle Scholar
- 5.G.C. Salmoraghi and B.D. Burns. Notes on mechanism of rhythmic respiration. J. Neurophysiol. 23:14 (1960).Google Scholar
- 6.A. Hugelin and M.I. Cohen. The reticular activating system and respiratory regulation in the cat. Ann. N. Y. Acad. Sci. 109:586 (1963).PubMedCrossRefGoogle Scholar
- 7.T. Trippenbach, G. Kelly and D. Mariot. Respiratory effects of stimulation of intercostal muscles and saphenous nerve in kittens. J. A. Physiol. 54:1736 (1983).Google Scholar
- 8.O.A.M. Wyss. The part played by the lungs in the reflex control of breathing. Helv. Physiol. Acta. 12 Suppl. 10:103 (1954).Google Scholar
- 9.T. Trippenbach, G. Kelly and D. Mariot. Effects of tonic vagal activity on breathing pattern in newborn rabbits. J. Appl. Physiol. 59:223 (1985).PubMedGoogle Scholar
- 10.T. Trippenbach and G. Kelly. Respiratory effects of cigarette smoke, dust and histamine in newborn kittens. J. Appl. Physiol. 64:837 (1988).PubMedGoogle Scholar
- 11.M. D. Parrish, J.M. Hill and M.P. Kaufman. Cardiovascular and respiratory responses to static exercise in the newborn kitten. Pediatr. Res. 30:95 (1991).PubMedCrossRefGoogle Scholar
- 12.M. Seatta and J.P. Mortola. Interaction in hypoxic and hypercapnic stimuli on breathing pattern in the newborn rat. J. Appl. Physiol. 62:506 (1987).Google Scholar
- 13.J.P. Schade. Maturational aspects of EEG and of spreading depression in rabbits. J. Neurophysiol. 22:245 (1959).PubMedGoogle Scholar
- 14.K.L. Engish and G.D. Fischbach. The development of ACH-and GABA-activated currents in normal and target-deprived embryonic chick ciliary ganglia. Dev. Biol. 139:417 (1990).CrossRefGoogle Scholar