Dynamical Analysis of the Ventilatory Response to Changes in Peto2: Separation of Central and Peripheral Effects
In adult humans and animals as well as in newborns the ventilatory response to an isocapnic stepwise change in end-tidal PO2 (PETO2) shows an initial fast increase frequently followed by a slow decline.1, 2, 3, 4, 5 The ventilatory increase is generally ascribed to an increased drive from the peripheral chemoreceptors. The mechanism of the subsequent hypoxic ventilatory depression is not well understood.6 To gain insight into the mechanism of this depression it is necessary to first separate and quantify stimulatory and depressant effects. An attractive technique to do this is the dynamic end-tidal forcing (DEF) technique, since it is non-invasive and can therefore be applied to human beings. However, for the dynamical analysis of the experimental data a mathematical model is needed, the validation of which is not easy a task.
KeywordsDepressant Effect Ventilatory Response Peripheral Effect Artificial Perfusion Peripheral Chemoreceptor
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