Electrophysiological and Anatomical Studies of the Second Order Neurons in the Reflex Pathway from Pulmonary Rapidly Adapting Receptors in the Cat

  • Kazuhisa Ezure
  • Kazuyoshi Otake
  • Janusz Lipski
  • Richard B. Wong She

Abstract

Pulmonary rapidly adapting receptors (RARs)7, also known as lung irritant receptors, elicit various respiratory reflexes including increase of inspiratory activity and shortening of expiration, increase of respiratory frequency (tachypnea), augmented breaths (sighs), coughing, mucus secretion and bronchoconstriction2, 10, 11. Despite the large number of reports on the properties of RARs, there have been relatively few studies on the central pathways through which the respiratory reflexes evoked by the activation of these receptors are mediated. The projections and central terminations of afferent fibers originating from RARs have been traced to the nucleus of the solitary tract (NTS) with antidromic mapping4, spike-triggered averaging of field potentials8, and intraaxonal labeling with HRP. The presence of second order neurons was suggested in the medial and caudal portion of the NTS, especially in the commissural subnucleus (COM) caudal to the obex in both the cat8 and the rat1.

Keywords

Caudal Portion Dorsal Motor Nucleus Efferent Projection Order Neuron Phrenic Nerve Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    A.C. Bonham and McCrimmon, D.R., Neurones in a discrete region of the nucleus tractus solitarius are required for the Breuer-Hering reflex in rat, J. Physiol. (Lond.), 427: 261–280 (1990).Google Scholar
  2. 2.
    H.M. Coleridge and J.C.G. Coleridge, Reflexes evoked from tracheobronchial tree and lungs. In N.S. Cherniack and J.G. Widdicombe (Eds.), Handbook of Physiology. Section 3, The Respiratory System Vol. II. Control of Breathing, American Physiological Society, Washington, DC, pp 395–429 (1986).Google Scholar
  3. 3.
    C.A. Connelly, H.H. Ellenberger and J.L. Feldman, Respiratory activity in retrotrapezoid nucleus in cat. Am. J. Physiol. 258 (Lung Cell. Mol. Physiol. 2): L33–L44 (1990).PubMedGoogle Scholar
  4. 4.
    R.O. Davies and L. Kubin, Projection of pulmonary rapidly adapting receptors to the medulla of the cat: an antidromic mapping study, J. Physiol. (Lond.), 373: 63–86 (1986).Google Scholar
  5. 5.
    K. Ezure, K. Otake, J. Lipski and R.B. Wong She, Efferent projections of pulmonary rapidly adapting receptor relay neurons in cats, Brain Res., 564: 268–278 (1991).PubMedCrossRefGoogle Scholar
  6. 6.
    M. Kalia and D. Richter, Rapidly adapting pulmonary receptor afférents: I. arborization in the nucleus of the tractus solitarius, J. Comp. Neurol., 274: 560–573 (1988).PubMedCrossRefGoogle Scholar
  7. 7.
    G.C. Knowlton and M.G. Larrabee, A unitary analysis of pulmonary volume receptors, Am. J. Physiol., 147: 100–114 (1946).PubMedGoogle Scholar
  8. 8.
    L. Kubin and R.O. Davies, Sites of termination and relay of pulmonary rapidly adapting receptors as studied by spike-triggered averaging, Brain Research, 443: 215–221 (1988).PubMedCrossRefGoogle Scholar
  9. 9.
    J. Lipski, K. Ezure and R.B. Wong She, Identification of neurons receiving input from pulmonary rapidly adapting receptors in the cat, J. Physiol. (Lond.), 443: 55–77 (1991).Google Scholar
  10. 10.
    G. Sant’Ambrogio, Information arising from the tracheobronchial tree of mammals, Physiol. Rev., 62: 531–569 (1982).Google Scholar
  11. 11.
    J.G. Widdicombe, Pulmonary and respiratory tract receptors, J. Exp. Biol., 100: 41–57 (1982).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Kazuhisa Ezure
    • 1
  • Kazuyoshi Otake
    • 2
  • Janusz Lipski
    • 3
  • Richard B. Wong She
    • 3
  1. 1.Department of NeurobiologyTokyo Metropolitan Institute for NeuroscienceTokyoJapan
  2. 2.Department of AnatomyTokyo Medical and Dental UniversityTokyo 113Japan
  3. 3.Department of PhysiologyUniversity of AucklandAucklandNew Zealand

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