The Hammersmith Philosophy for PET Chemistry Automation
Clinical scientific research using PET requires access to a wide variety of radio-pharmaceuticals. We have chosen only to automate the production of those accessible via robust chemical syntheses. Three types of system are in routine use on a weekly scheduled basis. They are for [18F]-2 fluoro-2 deoxy-D-glucose([18F]FDG) production, [11C]-methylations and H2 15O infusions. As most PET Radiopharmaceutical syntheses generally require only control of valves, temperature, time and flow, we have chosen to use industrial programmable logic controllers (PLC’s) with sensing and feedback of temperature and multiport valve position where essential. “Set up” and “run” programmes are assembled in “ladder logic” and stored on an erasable programmable read only memory (EPROM). During the “set up” procedure clean dry reaction vessels, SEP- PAC®s, precursors, reagents, filters and product reception vials are installed. During the “run” sequence the processing proceeds automatically the operator intervenes only to“cut” the preparative HPLC product peak by remote control valve operation. For [HC] — methylations an automated product formulation system is integrated with the HPLC “cut peak” and delivers the product via a membrane filter to the delivery vial. A PLC controlled [18F]FDG unit, incorporating a closed glassy carbon reactor in a one pot system for fluorination and hydrolytic deprotection has been built. Enriched H2 18O is recovered and the product is terminally purified by HPLC.
KeywordsReaction Vessel Reaction Vial Ammonium Dihydrogen Phosphate Hydriodic Acid Rotary Valve
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