Routine Production of [18F]F2 from 11 MeV Proton-Only Cyclotron and Its Use for the Synthesis of 18F-Tracers for Heart and Brain

  • R. Chirakal
  • G. Firnau
  • M. Adams
  • G. J. Schrobilgen
  • G. Coates
  • G. T. Bida
  • E. S. Garnett

Abstract

Although an increasing number of PET centres are using small proton-only cyclotrons for routine production of 18F-labelled radiopharmaceuticals, only a few reports1,2,3 have been published on the routine production of electrophilic fluorine using the 18O(p,n)18F reaction. Nickels et al. 4 first reported a “one-shoot” and a “two-shoot” method to produce [18F]F2 from 18O-gas target. The “two-shoot” method is highly attractive because it allows quantitative recovery of 18O-gas from the target. In this paper we report our experiences during the first year of operation, using a Siemens RDS 112 (11 MeV proton-cyclotron), with the “two-shoot” approach to the routine production of [18F]F2 for radiopharmaceutical synthesis.

Keywords

Production Shoot Target Chemistry Routine Production Direct Fluorination Radiopharmaceutical Chemistry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • R. Chirakal
    • 1
  • G. Firnau
    • 1
  • M. Adams
    • 2
  • G. J. Schrobilgen
    • 2
  • G. Coates
    • 2
  • G. T. Bida
    • 3
  • E. S. Garnett
    • 1
  1. 1.Department of Nuclear MedicineMcMaster University Medical CentreHamiltonCanada
  2. 2.Department of ChemistryMcMaster UniversityHamiltonCanada
  3. 3.CTI PET SystemsUSA

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