MHC Control of Odortypes in the Mouse

  • Kunio Yamazaki
  • Gary K. Beauchamp
  • Yoshihisa Imai
  • Judith Bard
  • Lewis Thomas
  • Edward A. Boyse

Abstract

Odortypes, defined as genetically-determined body odors that enable individuals of a species to distinguish one another by odor, are specified in part by polymorphic genes of the Major Histocompatibility Complex or MHC. The participation of the MHC in individual odor constitution may shed light on evolutionary and developmental functions of the MHC (Beauchamp et al., 1986; Boyse et al., 1987, 1991; Yamazaki et al., 1991). These functions have long been suspected to account for many non-immunological correlates of MHC polymorphism which have no obvious connection with the precisely defined immunological functions of the MHC (review in Boyse et al., 1983), but which may signify more rudimentary functions that preceded the specific adaptive immunity which is fully manifested only in vertebrates.

Keywords

Major Histocompatibility Complex Major Histocompatibility Complex Gene Congenic Mouse Major Histocompatibility Complex Region Major Histocompatability Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Kunio Yamazaki
    • 1
  • Gary K. Beauchamp
    • 1
  • Yoshihisa Imai
    • 1
  • Judith Bard
    • 2
  • Lewis Thomas
    • 3
  • Edward A. Boyse
    • 2
  1. 1.Monell Chemical Senses CenterPhiladelphiaUSA
  2. 2.Department of Microbiology and ImmunologyUniversity of Arizona Health Sciences CenterTucsonUSA
  3. 3.New York Hospital/Cornell Medical CenterNew YorkUSA

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