α Gustducin: A Taste Cell Specific G Protein Subunit Closely Related to the α Transducins

  • Susan K. McLaughlin
  • Peter J. McKinnon
  • Robert F. Margolskee

Abstract

The guanine nucleotide binding proteins (G proteins) mediate signal transduction in olfactory, visual, hormonal and neurotransmitter systems (see Birnbaumer, 1990). The G proteins comprise a gene family of proteins which transduce an extracellular signal into an intracellular second messenger (e.g. cAMP, cGMP, IP3). Many different cell surface receptors couple to and interact with specific subtypes of G proteins. All G proteins are heterotrimers (αßγ) wherein the α subunit binds guanine nucleotides and contains most, if not all, of the specificity for both receptor and effector interactions.

Keywords

Taste Cell RNase Protection Assay Guanine Nucleotide Binding Protein cAMP Phosphodiesterase Fungiform Papilla 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Susan K. McLaughlin
    • 1
  • Peter J. McKinnon
    • 1
  • Robert F. Margolskee
    • 1
  1. 1.Roche Research CenterRoche Institute of Molecular BiologyNutleyUSA

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