Modulation by Polyunsaturated Lipid Diets of Nitrosamine-Induced Cancers in Rats: Effects on Prooxidant State and Drug Metabolism
Dietary lipids are associated with increased risks for certain types of cancer, especially those of the breast and colon. This enhancing effect has been documented in humans by epidemiological studies1,2,3, as well as by studies in experimental animals4,5,6,7,8. Although the association between dietary lipids and carcinogenesis has been known for a long time, the molecular mechanism by which lipids modulate tumor development remains largely unknown.
KeywordsDietary Lipid Ethane Production Monooxygenase Activity NADPH Production Extrahepatic Tumor
Unable to display preview. Download preview PDF.
- 5.K. K. Carroll and M. B. Davidson, The role of lipids in tumorigenesis, in: “Molecular Interrelations of Nutrition and Cancer”, M. S. Arnott, J. Van Eys and Y.-M. Wang, eds., Raven Press, New York (1982).Google Scholar
- 7.A. F. Watson and E. Mellanby, Tar cancer in mice. II: The condition of the skin when modified by external treatment or diet, as a factor in influencing the cancerous reaction, Br. J. Exp. Pathol. 11:311 (1930).Google Scholar
- 8.A. Tannenbaum, Nutrition and cancer, in: “The Physiopathology of Cancer”, 2nd ed., F. Homburger, ed., Hoeber-Harper, New York (1959).Google Scholar
- 9.E. Hietanen, M. Ahotupa, J.-C. Béréziat, V. Bussacchini, A.-M. Camus and H. Bartsch, Elevated lipid peroxidation in rats induded by dietary lipids and N-nitrosodimethylamine and its inhibition by indomethacin monitored via ethane exhalation, Toxicol. Pathol. 15:93 (1987).PubMedCrossRefGoogle Scholar
- 19.E. Hietanen, C. Malaveille, A.-M. Camus, J.-C. Béréziat, G. Brun, M. Castegnaro, J. Michelon, J. R. Idle and H. Bartsch, Interstrain comparison of hepatic and renal microsomal carcinogen metabolism and liver S9-mediated mutagenicity in DA and Lewis rats phenotyped as poor and extensive metabolizers of debrisoquine, Drug Metab. Dispos. 14:118 (1986).PubMedGoogle Scholar
- 21.W. P. Norred and A. E. Wade, Dietary fatty-acid-induced alterations of hepatic microsomal drug metabolism, Biochem. Pharmacol. 238:292 (1972).Google Scholar
- 25.J. A. Miller, B. E. Kline, H. P. Rush and C. A. Baumann, The effect of certain lipids on the carcinogenicity of p-dimethylaminoazobenzene, Cancer Res. 4:756 (1944).Google Scholar
- 27.A. G. Hildebrandt, C. Bergs, G. Heinemeyer, E. Schiede, J. Roots, P. Abbas-Ali and A. Schmoldt, Studies on the mechanism of stimulation of microsomal H2O2 formation and benzo(a)pyrene hydroxylation by substrates and flavone, Adv. Exp. Med. Biol. 136A:179 (1982).Google Scholar
- 28.W. E. M. Lands, R. J. Kulmacz and P. J. Marshall, Lipid peroxide actions in the regulation of prostaglandin biosynthesis, in: “Free Radicals in Biology”, vol. VI, W. A. Pryor, ed., Academic Press, New York (1984).Google Scholar