Role of Intermediate Filaments and Ubiquitin in Protein Catabolism in Tumor Cells

  • Rupert Earl
  • Heather Mangiapane
  • Daniel Tuckwell
  • Simon Dawson
  • Michael Landon
  • Michael Billet
  • James Lowe
  • R. John Mayer

Abstract

Coordinate stimulation of protein synthesis and inhibition of protein catabolism generally follows the addition of hormones or growth factors to cells bearing the requisite receptors. This anabolic effect may occur constitutively in transformed cells during exponential phases of growth. Cessation of growth in certain tumor cell lines, e.g. at high density, can be achieved by a large increase in protein degradation together with a significant decrease in protein synthesis. It is even possible that tumor cell death is accompanied by high protein catabolic rates mediated by the acid vesicular system1.

Keywords

Intermediate Filament Protein Catabolism Rous Sarcoma Virus Sendai Virus Human Astrocytoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Rupert Earl
    • 1
  • Heather Mangiapane
    • 1
  • Daniel Tuckwell
    • 1
  • Simon Dawson
    • 1
  • Michael Landon
    • 1
  • Michael Billet
    • 1
  • James Lowe
    • 1
  • R. John Mayer
    • 1
  1. 1.Department of BiochemistryUniversity of Nottingham Medical School, Queen’s Medical CentreNottinghamUK

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