Role of Intermediate Filaments and Ubiquitin in Protein Catabolism in Tumor Cells
Coordinate stimulation of protein synthesis and inhibition of protein catabolism generally follows the addition of hormones or growth factors to cells bearing the requisite receptors. This anabolic effect may occur constitutively in transformed cells during exponential phases of growth. Cessation of growth in certain tumor cell lines, e.g. at high density, can be achieved by a large increase in protein degradation together with a significant decrease in protein synthesis. It is even possible that tumor cell death is accompanied by high protein catabolic rates mediated by the acid vesicular system1.
KeywordsIntermediate Filament Protein Catabolism Rous Sarcoma Virus Sendai Virus Human Astrocytoma
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- 6.A. J. Ingram, S. Dawson, R. T. Earl, H. E. Mangiapane and R. J. Mayer, Reversible intermediate filament collapse with concomitant reversible cytoplasmic retraction results in rapid perinuclear sequestration of viral membrane proteins before degradation, Biochem. J. submitted.Google Scholar
- 12.J. Lowe, A. Blanchard, K. Morrell, G. Lennox, L. Reynolds, M. Billet, M. Landon and R. J. Mayer, Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, J. Pathol. submitted.Google Scholar