Susceptibility of grc-Bearing Rats to DEN and Its Relationship to the HMP Pathway
The genetic factors underlining the susceptibility to cancer have been examined in a number of experimental1 and clinical2 settings, and there is substantial evidence for the existence of such factors. Studies in both rats3 and mice4 have provided evidence that genes linked to the major histocompatibility complex (MHC) play an important role in the susceptibility to cancer following exposure to chemical carcinogens. Previously, we3 showed that two strains that differ in their MHC’s (RT1) and in the presence of the MHC-linked growth and reproduction complex (grc) differed in their susceptibility to the chemical carcinogen N-2-acetylaminofluorene (AAF). The R10 (RT1.A n B ℓ D ℓ E − grc) and BY1 (RT1.A ℓ B ℓ D ℓ E • grc) strains were highly susceptible to AAF, whereas the BI (A n B a D a E u grc +) and BY2 (A u B u D u E u grc +) strains were not. These findings indicated that genes in, or linked to, the MHC were involved in the increased susceptibility to preneoplastic changes and suggest that the presence of the grc is critical in determining this susceptibility.
KeywordsMajor Histocompatibility Complex G6PD Deficiency Chemical Carcinogen Acinar Cell Carcinoma G6PD Activity
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