A Cell Culture Model for Study of Chemically-Derived and Spontaneous Mouse Lung Alveologenic Carcinoma

  • Garry J. Smith
  • Jacqueline M. Bentel
  • Tarja A. Savolainen
  • John G. Steel
  • Christine K. Loo

Abstract

Lung adenomas are among the most common tumors of mice and may occur spontaneously or be induced by carcinogens such as urethane1. A proportion of the benign adenomas reportedly progress to adenocarcinomas1. The alveolar adenoma is believed to derive from an epithelial cell of lung alveolus, the type II pneumocyte.

Keywords

Cell Strain Mouse Lung Benign Adenoma Australia Introduction Lung Alveolus 
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References

  1. 1.
    M. B. Shimkin and G. D. Stoner, Lung tumours in mice: Application to carcinogenesis bioassay, Adv. Cancer Res. 21:1 (1975).PubMedCrossRefGoogle Scholar
  2. 2.
    G. J. Smith, R. K. Kumar, C. P. Hristoforidis and A. W. J. Lykke, Expression of a type 2 pneumocyte-specific antigen by a cell strain from normal adult mouse lung, Cell Biol. Int. Reports 9:1115 (1985).CrossRefGoogle Scholar
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    G. J. Smith and J. M. Bentel, Malignant epithelial cell strains cultured from BALB/cmouse lung adenoma, Cell Biol. Int. Reports 11:111 (1987).CrossRefGoogle Scholar
  4. A. G. J. Smith, F. A. Bennet, J. G. Steele and J. M. Bentel, Onset of neoplastic phenotype in an epithelial cell strain from adult BALB/c mouse lung alveolus, J. Natl. Cancer Inst. 76:73 (1986).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Garry J. Smith
    • 1
  • Jacqueline M. Bentel
    • 1
  • Tarja A. Savolainen
    • 1
  • John G. Steel
    • 2
  • Christine K. Loo
    • 1
  1. 1.Carcinogenesis Research Unit, School of PathologyUniversity of New South WalesKensingtonAustralia
  2. 2.Division of Molecular BiologyC.S.I.R.ONorth RydeAustralia

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