Interaction of Activated N-Nitrosamines with DNA

  • Jamie R. Milligan
  • Laura Catz-Biro
  • Samim Hirani-Hojatti
  • Michael C. Archer

Abstract

Some chemically induced tumors in rodents are associated with single point mutations in ras genes1. It is important to know whether these mutations arise at sites in DNA of unusually high reactivity for ultimate carcinogens, or whether carcinogen interaction is random. This information is not available for simple methylating agents such as those derived from N-nitroso compounds.

Keywords

Single Point Mutation Plasmid pBR322 Methylating Agent Methyl Phosphate Apurinic Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Jamie R. Milligan
    • 1
  • Laura Catz-Biro
    • 1
  • Samim Hirani-Hojatti
    • 1
  • Michael C. Archer
    • 1
  1. 1.Department of Medical BiophysicsUniversity of Toronto Ontario Cancer InstituteTorontoCanada

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