Aminopeptidase P

A Cell-Surface Antigen of Endothelial and Lymphoid Cells
  • Jürgen Lasch
  • Sylke Moschner
  • Regine Koelsch
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 421)

Abstract

Many mammalian cell-surface proteins are linked posttranslationally to complex glycosyl phosphatidylinositol (GPI) anchors which associate these proteins with the outer leaflet of the plasma membrane (type V membrane proteins). At least 50 of such proteins are known today in mammals. GPI-proteins include complement regulatory factors 1, cell adhesion molecules 2, receptors of the Fc part of immunoglobulins 2, ADP-ribosyltransferases 3 and ectoenzymes 4, e.g. aminopeptidase P 5.6.7.. They have been found on a variety of cells including endothelial cells 8. They differ from peptide-anchored transmembrane proteins (type I – IV membrane proteins) in cell-surface distribution, lateral mobility and lipid environment 9.

Keywords

Outer Leaflet Relative Light Unit Human Aortic Endothelial Cell Stratum Corneum Lipid Myeloid Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Jürgen Lasch
    • 1
  • Sylke Moschner
    • 1
  • Regine Koelsch
    • 1
  1. 1.Institute of Physiological Chemistry Medical FacultyMartin-Luther-UniversityHalleGermany

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