Chemical Modeling with p-Boronophenylalanine for Boron Accumulation to and Release from Melanoma

  • Kazuo Yoshino
  • Yoshihiro Mori
  • Hidetake Kakihana
  • Hiroaki Takahashi
  • Yutaka Mishima
  • Masamitsu Ichihashi

Abstract

This paper describes a proposed mechanism of boron accumulation to and release from melanoma after administration of p-Boronophenylalanine (p-BPA) to melanoma patients. The study is based on chemical experiments modeling the phenomena occurring in melanoma cells. Before the mechanism study, we would like to mention the history of the BNCT compound, p-BPA.

Keywords

Melanoma Cell Boric Acid Boronic Acid Boron Neutron Capture Therapy Melanin Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Kazuo Yoshino
    • 1
  • Yoshihiro Mori
    • 1
  • Hidetake Kakihana
    • 2
  • Hiroaki Takahashi
    • 1
  • Yutaka Mishima
    • 3
  • Masamitsu Ichihashi
    • 4
  1. 1.Department of Chemistry, Faculty of ScienceShinshu UniversityAsahi Matsumoto 390Japan
  2. 2.Energy Research Center Wakasa BayTsuruga 914Japan
  3. 3.Mishima Skin ClinicMishima Institute for Dermatological ResearchKobe 657Japan
  4. 4.Kobe University School of MedicineKobe 650Japan

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