Noninvasive in-vivo Detection of Boron-10 by Magnetic Resonance
One of the major problems associated with the successful clinical implementation of boron neutron capture therapy (BNCT), is the ability to determine boron-10 concentrations in the tumor and the surrounding tissue in the treated patient, during and following the infusion of the BNCT agents. In this chapter we describe the results of pilot experiments conducted in an animal model, aimed at evaluating the potential of nuclear magnetic resonance (NMR) to perform this task, and extrapolate from these results to the expected performance in human patients.
KeywordsNuclear Magnetic Resonance Boron Neutron Capture Therapy Indirect Detection Spin Quantum Number Nuclear Magnetic Resonance Detection
Unable to display preview. Download preview PDF.
- 1.D.D. Stark and W.G. Bradley, eds., “Magnetic Resonance Imaging”, Mosby, St. Louis, 1992 Vol. 1.Google Scholar
- 3.P. Bendel, M. Davis, E. Berman, and G.W. Kabalka, A method for imaging nuclei with short T, relaxation and its application to boron-11 MR imaging of a BNCT agent in an intact rat, J. Magn. Reson. 88: 369–375, 1990.Google Scholar
- 5.K. M. Bradshaw, T.L. Richards, and S.L. Kraft, In-vivo pharmacokinetic evaluation of boron compounds using magnetic resonance spectroscopy and imaging, in: “Progress in Neutron Capture Therapy for Cancer,” B.J. Allen, D.E. Moore, and S.V. Harrington, eds., Plenum Press, New-York, 1992, pp. 325–330.CrossRefGoogle Scholar
- 10.E.I. Tolpin, G.R. Wellum, and S.A. Berley, Synthesis and chemistry of mercapto/undecahydro-closo-dodecaborate(2-), lnorg. Chem. 17: 2867–2873, 1978.Google Scholar
- 11.M. Suzuki, and R. Kubo, Theoretical calculation ofN.M.R. spectral line shapes, Molec. Phys. 7: 201–209, 1964.Google Scholar
- 12.A. Abragam, “Principles of Nuclear Magnetism,” Clarendon Press, Oxford, 1989.Google Scholar
- 13.D.I. Hoult, and P.C. Lauterbur, The sensitivity of the zeugmatographic experiment involving human samples, J. Magn. Reson. 34: 425–433, 1979.Google Scholar
- 14.C-N. Chen, and D.I. Hoult, `Biomedical Magnetic Resonance Technology“, Adam Hilger, Bristol, 1989 pp. 130.Google Scholar