Application of Neutron-Induced Prompt Gamma-Ray Analysis for Determination of B-10 in BNCT

  • Chushiro Yonezawa
  • Hideaki Matsue
  • Hiroyuki Sawahata
  • Tatsuya Kurosawa
  • Michio Hoshi
  • Yasuo Ito

Abstract

Twenty-six brain tumor patients have been treated with the boron neutron capture therapy (BNCT) at the JRR-2, Japan Atomic Energy Research Institute (JAERI)1, since 1990. An accurate analysis of ppm levels of 10B content in tissues is essential for determining neutron irradiation dose in the BNCT. Although the ppm level of 10B can be analyzed by destructive analytical methods of inductively coupled plasma atomic emission spectrometry (ICP-AES) and spectrophotometry, due to the necessity of sample decomposition, these methods are not suitable when quick analysis is required for determining the neutron irradiation dose before the BNCT treatment. A neutron-induced prompt γ-ray analysis (PGA)2 is characterized by the capability of nondestructive 10B analysis. On account of large cross section of the reaction 10B(n,α)7*Li (σ = 3837 barn), the Doppler broadened 478 keV photo-peak is observed with the highest sensitivity by the PGA. The 10B in the tissues was determined by measuring the 478 keV peak area against the 2223 keV peak area for the 1H as an internal standard3,4.

Keywords

Inductively Couple Plasma Atomic Emission Spectrometry Neutron Beam Boron Neutron Capture Therapy Brain Tumor Patient Japan Atomic Energy Research Institute 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    E.Shirai, H.Takahashi, M.Issiki, K.Arigane, M.Iwaya, H.Hatanaka, Y.Hayakawa and Y.Nakagawa, Clinical experience of BNCT for brain tumours at JAERI, in: “Progress in Neutron Capture Therapy for Cancer”, B.J.Allen, D.E.Moore and B.V.Harrington, ed., Prenum Press, New York, 1992, pp. 569–576.Google Scholar
  2. 2.
    R.E.Chrien, Practical uses of neutron capture gamma-ray spectroscopy, in: “Neutron Radiative Capture”, B.J.Allen, I.Berggvist, R.E.Chrien, D.Gardner and W.P.Poenitz, ed., Pergamon Press, Oxford, 1984. pp. 187–213.Google Scholar
  3. 3.
    T. Kobayashi and K. Kanda, Microanalysis system of ppm-order 1°B concentration in tissue for neutron capture therapy by prompt y-ray spectrometry, Nucl. Instrum. Methods 204: 525–531, 1983.CrossRefGoogle Scholar
  4. 4.
    T. Matsumoto and O. Aizawa, Prompt y-ray neutron activation analysis of B-10 in biological materials, Appl. Radial. Ism. 41: 897–903, 1990.CrossRefGoogle Scholar
  5. 5.
    C. Yonezawa, A.K. Haji Wood, M. Hoshi, Y. Ito and E. Tachikawa, The characteristics of the prompt y-ray analyzing system at the neutron beam guides of JRR-3M, Nucl. Instrum. Methods A329: 207–216, 1993.CrossRefGoogle Scholar
  6. 6.
    C. Yonezawa, Prompt y-ray analysis of elements using cold and thermal reactor guided neutron beams. Anal Sci. 9: 185–193, 1993.CrossRefGoogle Scholar
  7. 7.
    C. Yonezawa, M. Magara, H. Sawahata, M. Hoshi, Y. Ito and E.Tachikawa, Prompt y-ray analysis using cold and thermal guided neutron beams, J. Radioanal. Nucl. Chem. 193: 171–178, 1995.CrossRefGoogle Scholar
  8. 8.
    T.Kobayashi, K.Aoki, M.Ono and K.Kanda, Measurement of 1°B concentrations and its location in phantom by prompt gamma-ray spectroscopy, in: “Neutron Capture Therapy”, H.Hatanaka, ed., Nishimura Co., Ltd., Niigata, 1986, pp. 2–7.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Chushiro Yonezawa
    • 1
  • Hideaki Matsue
    • 1
  • Hiroyuki Sawahata
    • 2
  • Tatsuya Kurosawa
    • 3
  • Michio Hoshi
    • 1
  • Yasuo Ito
    • 2
  1. 1.Department of Chemistry and Nuclear Fuel ResearchJapan Atomic Energy Research InstituteTokai-mura, Naka-gunJapan
  2. 2.Research Center for Nuclear Science and TechnologyThe University of TokyoTokai-mura, Naka-gunJapan
  3. 3.Radiation Application Development AssociationTokai-mura, Naka-gunJapan

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