Application of Neutron-Induced Prompt Gamma-Ray Analysis for Determination of B-10 in BNCT
Twenty-six brain tumor patients have been treated with the boron neutron capture therapy (BNCT) at the JRR-2, Japan Atomic Energy Research Institute (JAERI)1, since 1990. An accurate analysis of ppm levels of 10B content in tissues is essential for determining neutron irradiation dose in the BNCT. Although the ppm level of 10B can be analyzed by destructive analytical methods of inductively coupled plasma atomic emission spectrometry (ICP-AES) and spectrophotometry, due to the necessity of sample decomposition, these methods are not suitable when quick analysis is required for determining the neutron irradiation dose before the BNCT treatment. A neutron-induced prompt γ-ray analysis (PGA)2 is characterized by the capability of nondestructive 10B analysis. On account of large cross section of the reaction 10B(n,α)7*Li (σ = 3837 barn), the Doppler broadened 478 keV photo-peak is observed with the highest sensitivity by the PGA. The 10B in the tissues was determined by measuring the 478 keV peak area against the 2223 keV peak area for the 1H as an internal standard3,4.
KeywordsInductively Couple Plasma Atomic Emission Spectrometry Neutron Beam Boron Neutron Capture Therapy Brain Tumor Patient Japan Atomic Energy Research Institute
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