Chemical Behavior of Boron-Containing Amino Acids for Neutron Capture Therapy in Aqueous Solutions

  • Mitsue Kobayashi
  • Yoshinori Kitaoka

Abstract

Because of poor solubility of p-boronophenylalanine (BPA) in water, BPA-fructose complex has been used at clinical experiments of BNCT1. Complexation is a method of choice to improve the solubility of BPA2. Based on the electrophoretic behavior, we had reported that BPA formed negatively charged complexes with some carboxylic acids such as oxalic acid and citric acid3. Chemical states of BPA in aqueous oxalic acid and in aqueous fructose were investigated mainly by infrared (IR) spectroscopy. The chemical nature of dihydroxyboryl group of p-boronophenylserine (BPS) in the aqueous solutions was examined and compared with that of BPA.

Keywords

Oxalic Acid Boron Atom Calcium Fluoride Paper Electrophoresis Thermal Neutron Capture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Y. Mishima, C. Honda, M. Ichihashi, and M. Shiono, Cure of human malignant melanoma by thermal neutron capture therapy, KURRI-TR-357 (Kyoto University Research Reactor Institute-Technical Report-357): 40–45, 1991 (in Japanese).Google Scholar
  2. 2.
    K. Yoshino, A. Suzuki, Y. Mori, H. Kakihana, C. Honda, Y. Mishima, T. Kobayashi, and K. Kanda, Improvement of solubility of p-boronophenylalanine by complex lùrmation with monosaccharides, KURRI-TR-357: 145–147, 1991.Google Scholar
  3. 3.
    Y. Kitaoka, M. Kobayashi, and Y. Ujeno, Studies of the electrophoretic behaviour of p-dihydroxyborylphenylalanine and related compounds by the three-spot method, J. Chron alogr 585: 369–372, 1991.CrossRefGoogle Scholar
  4. 4.
    M. Kobayashi, Y. Kitaoka, Y. Tanaka and K. Kawamoto, Electrophoretic behaviour and infrared spectra of dihydroxyboryl compounds in aqueous di-and tricarboxylic acids: paper electrophoresis as a tool for determining the chemical states of a sub stance in solution,. 1. Chrommo r.•I 678: 351–358, 1994.Google Scholar
  5. 5.
    M. Kobayashi and K. Nishioka, Hydration ofN-monosubstituted amides in the binary solvents dioxaneD20 and Dioxane-H2O,.1. Phrs. Chem. 91: 1247–1251, 1987.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Mitsue Kobayashi
    • 1
  • Yoshinori Kitaoka
    • 1
  1. 1.Research Reactor InstituteKyoto UniversityOsaka 590-04Japan

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