The Transferrin Receptor and Iron Accumulation in Erythroid Cells

  • Klas Forsbeck
Part of the Blood Cell Biochemistry book series (BLBI, volume 1)

Abstract

Developing erythroid cells need large amounts of iron mainly for heme formation but also for other essential biochemical reactions. Several obstacles have to be overcome in order to get the iron distributed to the right place in sufficient quantity at the right time. In the ionic state, iron is reactive, potentially toxic, and poorly soluble. This imposes the need for appropriate carrier functions both outside and inside cells and during passage through hydrophobic membranes. The interval during erythroid differentiation with intense heme synthesis is limited, and creates a demand for an efficient iron extraction mechanism that can be turned on or shut off according to the actual iron requirement.

Keywords

K562 Cell Transferrin Receptor Erythroid Cell Iron Accumulation Human Transferrin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Klas Forsbeck
    • 1
  1. 1.Research and DevelopmentKabiStockholmSweden

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