Regulation of Antibiotic Biosynthesis

  • Giancarlo Lancini
  • Rolando Lorenzetti

Abstract

The principal mechanisms of regulation which apply to both primary and secondary metabolite biosynthesis are the repression of enzyme synthesis and the inhibition of enzyme activity. However, the fact that these operate in the control of secondary metabolite biosynthesis has only recently been well accepted. Some of these mechanisms are specific for antibiotic production but, remembering that secondary metabolism is a form of differentiation, it is not surprising that its regulation often falls under more general systems of control governing other forms of differentiation, such as the sporulation process or the formation of aerial mycelium.

Keywords

Secondary Metabolism Antibiotic Production Penicillium Chrysogenum Streptomyces Griseus Secondary Metabolite Biosynthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Demain, A. L., 1989, Carbon source regulation of idiolite biosynthesis in actinomycetes, in Regulation of Secondary Metabolism in Actinomycetes (S. Shapiro, ed.), pp. 127134, CRC Press, Boca Raton, Fla.Google Scholar
  2. Demain, A. L., 1992, Regulation of secondary metabolism, in Biotechnology of Filamentous Fungi ( D. B. Finkelstein and C. Ball, eds.), pp. 89–112, Butterworths/ Heinemann, London.Google Scholar
  3. Demain, A. L., Aharonowitz, Y., and Martin, J. F., 1983, Metabolic control of secondary biosynthetic pathways, in Biochemistry and Genetic Regulation of Commercially Important Antibiotics ( L. C. Vining, ed.), pp. 49–72, Addison-Wesley, Reading, Mass.Google Scholar
  4. Gräfe, U., 1989, Autoregulatory secondary metabolites from actinomycetes, in Regulation of Secondary Metabolism in Actinomycetes ( S. Shapiro, ed.), pp. 75–126, CRC Press, Boca Raton, Fla.Google Scholar
  5. Horinouchi, S., and Beppu, T., 1992, Autoregulatory factors and communication in Actinomycetes, Annu. Rev. Microbiol. 46: 377.PubMedCrossRefGoogle Scholar
  6. Malik, V. S., 1979, Regulation of chorismate-derived antibiotic production, Adv. Appl. Microbiol. 25: 75.PubMedCrossRefGoogle Scholar
  7. Malik, V. S., 1982, Genetics and biochemistry of secondary metabolism, Adv. Appl. Microbiol. 28: 27.CrossRefGoogle Scholar
  8. Martin, J. F., 1989, Molecular mechanisms for the control by phosphate of the biosynthesis of antibiotics and other secondary metabolites, in Regulation of Secondary Metabolism in Actinomycetes ( S. Shapiro, ed.), pp. 135–211, CRC Press, Boca Raton, Fla.Google Scholar
  9. Martin, J. F., and Demain, A. L., 1980, Control of antibiotic biosynthesis, Microbiol. Rev. 44: 230.PubMedGoogle Scholar
  10. Shapiro, S., 1989, Nitrogen assimilation in actinomycetes and the influence of nitrogen nutrition on actinomycete secondary metabolism, in Regulation of Secondary Metabolism in Actinomycetes ( S. Shapiro, ed.), pp. 135–211, CRC Press, Boca Raton, Fla.Google Scholar
  11. Vining, L. C., 1986, Secondary metabolism, in Biotechnology, Vol. 4 ( H. Pape and H.-J. Rehm, eds.), pp. 19–38, VCH Verlag, Weinheim.Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Giancarlo Lancini
    • 1
  • Rolando Lorenzetti
    • 1
  1. 1.MMDRI-Lepetit Research CenterGerenzano (Varese)Italy

Personalised recommendations