Significance of the Second Messenger Molecules in the Regulation of Cerebral Endothelial Cell Functions

An Overview
  • Ferenc Joó
Part of the Advances in Behavioral Biology book series (ABBI, volume 46)

Abstract

Several receptors for different vasoactive substances have been shown to be coupled to the microvascular adenylate cyclase and to increase the intraendothelial amount of cyclic AMP (Joó, 1986, 1992, 1993). As a consequence of elevated intraendothelial cyclic AMP, changes in permeability (Joó, 1972; Rubin et al. 1991), in endothelial growth and differentiation (Kempski et al. 1987), in nitric oxide and endothelin secretions (Durieu-Trautmann et al. 1993) and in a hyperpolarization-activated current carried by both Na+ and K+ ions (Janigro et al. 1994) have been reported. Elevations of cyclic AMP concentrations may be important in regulating the endothelial barrier in two-ways: (i) by narrowing the paracellular pathways for small molecular weight substances (Rubin et al. 1991), and (ii) activating the transendothelial transport for macromolecules (Joó, 1972). Recently, Grammas et al. (1994) found significantly elevated cAMP levels in microvessels from Alzheimer’s disease compared to nondemented elderly controls.

Keywords

Atrial Natriuretic Peptide Guanylate Cyclase Brain Capillary Endothelial Cell Cerebral Endothelial Cell Brain Microvessel Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Ferenc Joó
    • 1
  1. 1.Laboratory of Molecular NeurobiologyInstitute of Biophysics Biological Research CenterSzegedHungary

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