4-Oxo-Retinoic Acid Is Generated from Its Precursor Canthaxanthin and Enhances Gap Junctional Communication in 10T1/2 Cells
Retinoids and carotenoids inhibit the transformation of murine C3H/10T1/2 fibroblasts by chemical and physical carcinogens (Hossain et al., 1989; Pung et al., 1988). The protective ability of carotenoids was reported to be independent of their provitamin A activity and their ability to inhibit lipid peroxidation (Zhang et al., 1991). One of the most active carotenoids is canthaxanthin, which is not a known provitamin A in mammals (Bertram et al., 1991). The inhibitory effect of both retinoids and carotenoids towards neoplastic transformation correlates with their activity to induce gap junctional communication (Zhang et al., 1991; Bertram et al., 1991).
KeywordsRetinoic Acid Oxidation Fraction Cx43 mRNA Human Intestinal Mucosa Nuclear Retinoic Acid Receptor
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