4-Oxo-Retinoic Acid Is Generated from Its Precursor Canthaxanthin and Enhances Gap Junctional Communication in 10T1/2 Cells

  • Wilhelm Stahl
  • Michael Hanusch
  • Helmut Sies
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)

Abstract

Retinoids and carotenoids inhibit the transformation of murine C3H/10T1/2 fibroblasts by chemical and physical carcinogens (Hossain et al., 1989; Pung et al., 1988). The protective ability of carotenoids was reported to be independent of their provitamin A activity and their ability to inhibit lipid peroxidation (Zhang et al., 1991). One of the most active carotenoids is canthaxanthin, which is not a known provitamin A in mammals (Bertram et al., 1991). The inhibitory effect of both retinoids and carotenoids towards neoplastic transformation correlates with their activity to induce gap junctional communication (Zhang et al., 1991; Bertram et al., 1991).

Keywords

Retinoic Acid Oxidation Fraction Cx43 mRNA Human Intestinal Mucosa Nuclear Retinoic Acid Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Wilhelm Stahl
    • 1
  • Michael Hanusch
    • 1
  • Helmut Sies
    • 1
  1. 1.Institut für Physiologische Chemie I and Biologisch-Medizinisches ForschungszentrumHeinrich-Heine-Universität DüsseldorfDüsseldorfGermany

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