Serotonin Toxicity Causes Myodeterioration of Skeletal Muscle Function in Albino Mice
Serotonin (5-hydroxytryptamine, 5-HT) functions as a neurotransmitter affecting a variety of tissues, including gastrointestinal smooth muscle and striated limb muscle (Bulbring and Gershon, 1967; Ooms et al., 1986). It has also been shown to be a potent vasoconstricting agent (Carter, 1961). As a vasoconstrictor, serotonin causes decreased blood flow through capillaries to skeletal muscles. The decreased oxygen and nutrient exchange between blood and the “isolated” skeletal musculature results in changes in both histological appearance and muscle function (Erspamer, 1961). However, evidence suggesting that serotonin acts more directly on muscle cells has been reported. Attention has been given to studies testing the involvement of receptors responding to 5-HT stimulation in both vascular smooth muscle and skeletal muscle in an effort to discern the receptor subtype which may be in part responsible for the serotonin induced muscle myopathy. Interest has developed in attempting to determine which antagonists for distinct serotonin receptors will be effective therapeutically when administered to animal subjects suffering from serotonin induced myopathies.
KeywordsMuscle Preparation Sigma Receptor Skeletal Muscle Function Arterial Ligation Gastrointestinal Smooth Muscle
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- Branchek, T.A., Mawe, G.M., and Gershon, M.D. (1988). Characterization and localization of a peripheral neural 5-hydroxytryptamine receptor subtype (5-HT, ) with a selective agonist, H-hydroxyindalpine. J. Neurosci. 8, 7, 2582–2595.Google Scholar
- Bulbring, E. and Gershon, M.D. (1967). 5-HT participation in the vagai inhibitory innervation of the stomach. J. Physiol. 192, 823–846.Google Scholar
- Campbell, G.B., Scherz, M.W., Keana, J.F.W. and Weber, E. (1989). Sigma receptors regulate contractions of the guinea pig ileum longitudinal muscle/myenteric plexus preparation elicited by both electrical stimulation and exogenous serotonin. J. Neurosci. 9(10), 3380–3391.Google Scholar
- Cater, D.B., Garattini, S. and Silver, L.A. (1961). Changes of oxygen tension in brain and somatic tissues induced by vasodilator and vasoconstrictor drugs. Proc. Royal Soc. Lond. 33, 345–353.Google Scholar
- Clarke, D.E., Craig, D.A. and Fozard, J.R. (1989). The 5-HT4 receptor: naughty, but nice. TIPS, 10, 385–386.Google Scholar
- Kaumann, A.J. (in press) (1990). 5-HT receptors mediate positive inotropism in the human atrial appendage. Br. J. Pharmacol. Google Scholar
- Verheyen, A., Vlaminckx, E., Remeysen, P. and Borgers, M. (1981). The influence of ketanserin, a new S2 receptor antagonist on experimentally induced skeletal muscle myopathy in the rat. Virchows Arch. (A), 393:265–272.Google Scholar