Subacute Toxicity of Cyclopiazonic Acid in Broiler Chicks Fed Normal and High Zinc Diets

  • Mark E. Wilson
  • Winston M. HaglerJr.
  • Jon F. Ort
  • John M. Cullen
  • Richard J. Cole
Part of the Biodeterioration Research book series (BIOR, volume 3)

Abstract

Cyclopiazonic acid (CPA) was first isolated and identified as a toxic metabolite of Penicillium cyclopium Westling (Holzapfel, 1968). Corn and peanuts may be naturally contaminated with both CPA and aflatoxin B1 (Gallagher et al., 1978; Lansden and Davidson, 1983). Cyclopiazonic acid was relatively toxic in most animal studies (Purchase, 1971; Dorner et al., 1983; Lomax et al., 1984; Morrissey et al., 1984; Morrissey et al., 1985; Nuehring et al., 1985; Cullen et al., 1988; Wilson et al., 1989) and the 72 hr oral LD50 of CPA in day-old broiler chicks was 12 mg/kg body weight (BW) (Wilson et al., 1989).

Keywords

Broiler Chicken Plasma Zinc Dietary Zinc Cyclopiazonic Acid Broiler Chick 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Mark E. Wilson
    • 1
  • Winston M. HaglerJr.
    • 1
  • Jon F. Ort
    • 2
  • John M. Cullen
    • 3
  • Richard J. Cole
    • 4
  1. 1.Mycotoxin Laboratory, Department of Poultry ScienceNorth Carolina State UniversityRaleighUSA
  2. 2.Department of Poultry ScienceNorth Carolina State UniversityRaleighUSA
  3. 3.Department of Microbiology, Pathology, and Parasitology, College of Veterinary MedicineNorth Carolina State UniversityRaleighUSA
  4. 4.USDA/ARS, National Peanut Research LaboratoryDawsonUSA

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